3743-17-7

Basic information

• Product Name: N-(2-hydroxyphenyl)-4-nitrobenzamide
• Synonyms: benzamide, N-(2-hydroxyphenyl)-4-nitro-
• CAS NO: 3743-17-7
• Molecular Formula: C₁₃H₁₀N₂O₄
• Molecular Weight: 258.2295
• Mol File: 3743-17-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 369.9°C at 760 mmHg
• Flash Point: 177.5°C
• Density: 1.446g/cm³
• Vapor Pressure: 5.39E-06mmHg at 25°C
• Refractive Index: 1.703
• CAS DataBase Reference: N-(2-hydroxyphenyl)-4-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxyphenyl)-4-nitrobenzamide(3743-17-7)
• EPA Substance Registry System: N-(2-hydroxyphenyl)-4-nitrobenzamide(3743-17-7)

Safety Data

• Hazardous Substances Data: 3743-17-7(Hazardous Substances Data)

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 95-55-6 2-amino-phenol 
• 62-23-7 4-nitro-benzoic acid 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 86399-84-0 1-(4-nitro-benzoylamino)-2-(4-nitro-benzoyloxy)-benzene 
• 24367-68-8 N-(2-methoxyphenyl)-4-nitrobenzamide 
• 5099-12-7 4-Amino-N-(2-hydroxy-phenyl)-benzamide 
• 110809-18-2 Naphthalene-1-carboxylic acid 2-(4-nitro-benzoylamino)-phenyl ester 
• 840-58-4 2(4-nitrophenyl)benzoxazole 
• 132283-28-4 C₁₉⁽¹³⁾CH₁₄N₂O₅ 
• 13787-57-0 3-(4-nitro-benzoyl)-3H-benzooxazol-2-one 

Relevant articles and documents

Immobilized Carbodiimide Assisted Flow Combinatorial Protocol to Facilitate Amide Coupling and Lactamization

Through a screen of over one hundred and 30 permutations of reaction temperatures, solvents, carbodiimide resins, and carbodiimide molar equivalences, in the presence, absence, or combination of diisopropylamine and benzotriazole additives, a convenient and first reported carbodiimide polymer-assisted flow approach to effect amide coupling and lactamization was developed. The protocol entails injecting a single solution (1:9 dimethylformamide: dichloromethane) containing a carboxylic acid and an amine or linear peptide sequence into a continuous stream of dichloromethane. The protocol remained viable in the absence of base, did not require carboxylate preactivation which, and in concert with minimal workup requirements, enabled the isolation of products in high yields. Compared to the utilization of untethered carbodiimide reagents, the flow procedure was also observed to provide a degree of racemization safety.

Synthesis and microbiological activity of some N-(o-hydroxyphenyl)benzamides and phenylacetamides as the possible metabolites of antimicrobial active benzoxazoles: Part II

The synthesis of some N-(o-hydroxyphenyl)benzamides and benzacetamides (2a-2p) in order to determine their in vitro antimicrobial activity against two Gram-positive bacteria, three Gram-negative bacteria and the fungus Candida albicans is described. The new compounds were compared with several control drugs. The derivative 2g, 4-amino-N-(o-hydroxyphenyl)benzamide, was found active at an MIC value of 25 μg/ml against the Gram-negative microorganism Klebsiella pneumoniae. Most of the compounds exhibited antibacterial activity at an MIC value of 25 μg/ml against Pseudomonas aureginosa. For the antifungal activity against C. albicans, compounds 2e, 2h and 2m were found more active than the other derivatives (MIC 12.5 μg/ml). The antimicrobial activity of some of these benzamide and phenylacetamide derivatives (2a, 2b, 2f, 2g, 2h and 2k), possible metabolites of benzoxazoles, was also compared with that of the cyclic analogues 3-8. Compound 2f possesses two dilutions better antifungal activity than its cyclic analogue the benzoxazole derivative 5 against C. albicans, while having one dilution better antibacterial activity against Streptococcus faecalis and K. pneumoniae. (C) 2000 Elsevier Science S.A.