374602-79-6Relevant articles and documents
An Expedient Synthesis of LAF389, a Bengamide B Analogue
Xu, David D.,Repic, Oljan,Blacklock, Thomas J.,Waykole, Liladhar,Calienni, John V.,Ciszewski, Lech,Lee, George T.,Liu, Wenming,Szewczyk, Joanna,Vargas, Kevin,Prasad, Kapa
, p. 856 - 865 (2003)
An optimized, convergent, safe synthesis of LAF389 (9), an anticancer agent analogous to bengamide B, is described. Starting from α-D- glucoheptonic (D-glycero-D-gulo-heptonic acid) γ-lactone (10), the lactone 15 was constructed in five steps. Major impro
Use of certain substituted caprolactams in treating tumors
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, (2008/06/13)
The present invention relates to certain substituted caprolactam compounds, pharmaceutical compositions containing said compounds, the use of said compounds in treating tumors and to a process for making said compounds.