270902-51-7

Basic information

• Product Name: LAF389
• Synonyms: Cyclohexanecarboxylic acid 7-oxo-6(S)-[(2R,3R,4S,5R,6E)-3,4,5-trihydroxy-2-Methoxy-8,8-diMethyl-6-nonenaMido]perhydroazepin-3(R)-yl ester;LAF389
• CAS NO: 270902-51-7
• Molecular Formula: C25H42N2O8
• Molecular Weight: 498.60958
• Mol File: 270902-51-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: LAF389(CAS DataBase Reference)
• NIST Chemistry Reference: LAF389(270902-51-7)
• EPA Substance Registry System: LAF389(270902-51-7)

Safety Data

• Hazardous Substances Data: 270902-51-7(Hazardous Substances Data)

Upstream product

• 270902-68-6 (3S, 6R)-3-(tert-butoxycarbonyl)aminohexahydro-6-hydroxy-2H-azepin-2-one 
• 270902-69-7 (3S,6R)-3-(tert-butoxycarbonyl)aminohexahydro-6-(cyclohexanecarbonyl)-oxy-2H-azepin-2-one 
• 270902-70-0 (3S, 6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one 
• 270902-67-5 8,8-dimethyl-2-O-methyl-3,5-O-(1-methylethylidene)-6,7,8,9-tetradeoxy-D-gluo-6-nonenonic acid (6E)-γ-lactone 
• 270902-66-4 (4S,4aR,7R,7aR)-7-methoxy-2,2-dimethyl-6-oxotetrahydro-4H-furo[3,2-d][1,3]dioxine-4-carbaldehyde 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 2443-89-2 1,1-Diiodo-2,2-dimethylpropane 
• 270902-71-1 (2R,3R,4S,5R,6E)-3,5-(methylethylidene)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-N-[(3S,6R)-hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl]non-6-enamide 
• 6605-22-7 3,5:6,7-bis-O-(1-methylethylidene)-α-D-glucoheptonic γ-lactone 
• 2219-28-5 (R)-5-hydroxy-L-lysine dihydrochloride hydrate 
• 89-67-8 α-D-glucoheptonic γ-lactone 
• 374602-79-6 (3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl 
• 270902-65-3 (4R,4aS,7R,7aR)-4-((R)-1,2-dihydroxyethyl)-7-methoxy-2,2-dimethyltetra-hydro-6H-furo[3,2-d][1,3]dioxin-6-one 
• 136289-11-7 (4R,4aS,7R,7aR)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-7-methoxy-2,2-dimethyl-tetrahydro-6H-furo[3,2-d][1,3]dioxin-6-one 

Relevant articles and documents

CERTAIN SUBSTITUTED CAPROLACTAMS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN TREATING TUMORS

The present invention relates to certain substituted caprolactam compounds of formula (I), where R1 is (C1-6)alkyl or (C3-6)cycloalkyl; R2 is hydrogen or (C1-6)alkyl; X is (C1-12)alkylene; (C2-12)alkenylene; or (C2-12)alkynylene; m is 0 or 1; and R3 is (C

An Expedient Synthesis of LAF389, a Bengamide B Analogue

An optimized, convergent, safe synthesis of LAF389 (9), an anticancer agent analogous to bengamide B, is described. Starting from α-D- glucoheptonic (D-glycero-D-gulo-heptonic acid) γ-lactone (10), the lactone 15 was constructed in five steps. Major impro

Certain substituted caprolactams, pharmaceutical compositions containing them and a process for their preparation

The present invention relates to certain substituted caprolactam compounds of formula (I), where R1is (C1-6)alkyl or (C3-6)cycloalkyl; R2hydrogen or (C1-6)alkyl; X is (C1-12)alkynylene; (C