374791-58-9

Basic information

• Product Name: (RS)-N-(4-oxo-1-phenylcyclohexyl)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide
• Synonyms: (RS)-N-(4-oxo-1-phenylcyclohexyl)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide
• CAS NO: 374791-58-9
• Molecular Weight: 483.454
• Mol File: 374791-58-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (RS)-N-(4-oxo-1-phenylcyclohexyl)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-N-(4-oxo-1-phenylcyclohexyl)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide(374791-58-9)
• EPA Substance Registry System: (RS)-N-(4-oxo-1-phenylcyclohexyl)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide(374791-58-9)

Safety Data

• Hazardous Substances Data: 374791-58-9(Hazardous Substances Data)

Upstream product

• 85068-33-3 3,5-bistrifluoromethylphenyl acetic acid 
• 334477-38-2 (RS)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetic acid 
• 877056-25-2 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoyl chloride 
• 95261-39-5 4-amino-4-phenylcyclohexan-1-one 

Downstream Products

• 479195-27-2 3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-pyrrolidin-2-one 
• 479195-06-7 2-(3,5-bis-trifluoromethyl-phenyl)-4-hydroxy-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide 
• 479195-09-0 2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide 
• 479195-13-6 3-(3,5-bis-trifluoromethyl-phenyl)-3-methyl-1-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-pyrrolidin-2-one 
• 479195-11-4 3-(3,5-bis-trifluoromethyl-phenyl)-1-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-pyrrolidin-2-one 
• 877056-32-1 3-(3,5-bis-trifluoromethyl-phenyl)-3-methyl-1-(4-oxo-1-phenyl-cyclohexyl)-pyrrolidin-2-one 
• 479195-15-8 3-(3,5-bis-trifluoromethyl-phenyl)-1-(4-oxo-1-phenyl-cyclohexyl)-pyrrolidin-2-one 
• 479195-03-4 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide 

Relevant articles and documents

Novel lactam NK1 antagonists with anti-emetic activity

A series of 4,4-disubstituted cyclohexylamine NK1 antagonists containing a lactam ring is described. The compounds are brain penetrant and activity is demonstrated in a ferret emesis model.