877056-25-2Relevant articles and documents
Novel lactam NK1 antagonists with anti-emetic activity
Hollingworth, Gregory J.,Carlson, Emma J.,Castro, José L.,Chicchi, Gary G.,Clark, Natalie,Cooper, Laura C.,Dirat, Olivier,Di Salvo, Jerry,Elliott, Jason M.,Kilburn, Ruth,Kurtz, Marc M.,Rycroft, Wayne,Tattersall, F. David,Tsao, Kwei-Lan,Swain, Christopher J.
, p. 1197 - 1201 (2007/10/03)
A series of 4,4-disubstituted cyclohexylamine NK1 antagonists containing a lactam ring is described. The compounds are brain penetrant and activity is demonstrated in a ferret emesis model.