3760-95-0

Basic information

• Product Name: (R)-(+)-1,2-Epoxybutane
• Synonyms: (2R)-(+)-1,2-Epoxybutane, (2R)-(+)-2-Ethyloxirane;(2R)-(+)-3-Methyl-1,2-propenoxide 98+%;(R)-()-1,2-Butylene oxide;Oxirane, 2-ethyl-,(2R)-;(R)-(+)-1,2-Epoxybutane 98%;(R)-(+)-1,2-EPOXYBUTANE;(R)-1,2-EPOXYBUTANE;2R-ETHYLOXIRANE
• CAS NO: 3760-95-0
• Molecular Formula: C₄H₈O
• Molecular Weight: 72.11
• Product Categories: Chiral Compounds;Epoxides;API intermediates
• Mol File: 3760-95-0.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 63 °C(lit.)
• Flash Point: 10 °F
• Appearance: /
• Density: 0.837 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.386(lit.)
• CAS DataBase Reference: (R)-(+)-1,2-Epoxybutane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1,2-Epoxybutane(3760-95-0)
• EPA Substance Registry System: (R)-(+)-1,2-Epoxybutane(3760-95-0)

Safety Data

• Hazard Codes: F,T
• Statements: 20/21/22-34-40
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 3022 3/PG 2
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 3760-95-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Upstream product

• 106-88-7 ethyloxirane 
• 70379-72-5 (R)-2-acetoxy-1-bromobutane 
• 145021-04-1 (R)-1-tert-Butylsulfanyl-butan-2-ol 
• 124-38-9 carbon dioxide 
• 917-61-3 sodium isocyanate 
• 51-79-6 urethane 
• 56536-49-3 (2S)-2-chlorobutan-1-ol 
• 72952-76-2 S-(-)-1-bromo-2-acetoxy-butane 
• 136656-75-2 (R)-(-)-1-(benzenesulfanyl)-2-butanol 
• 93246-17-4 ((R)-2-Hydroxy-butyl)-trimethyl-ammonium; hydroxide 
• 40348-66-1 (R)-1,2-butanediol 

Downstream Products

• 1574555-38-6 (R)-1-(((1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)amino)butan-2-ol 
• 179396-48-6 (R)-1-(4-methoxyphenyl)butan-2-ol 
• 408523-27-3 (R)-1-(2-ethylphenyl)butan-1-ol 
• 67253-47-8 (R)-2-hydroxypropane-1-phenylsulfide 
• 198561-27-2 (R)-3-hydroxypentanenitrile 
• 1429383-27-6 (R)-1-((3,4-dimethoxybenzyl)oxy)butan-2-ol 

Relevant articles and documents

Aromatic Donor-Acceptor Interaction-Based Co(III)-salen Self-Assemblies and Their Applications in Asymmetric Ring Opening of Epoxides

Aromatic donor-acceptor interaction as the driving force to assemble cooperative catalysts is described. Pyrene/naphthalenediimide functionalized Co(III)-salen complexes self-assembled into bimetallic catalysts through aromatic donor-acceptor interactions and showed high catalytic activity and selectivity in the asymmetric ring opening of various epoxides. Control experiments, nuclear magnetic resonance (NMR) spectroscopy titrations, mass spectrometry measurement, and X-ray crystal structure analysis confirmed that the catalysts assembled based on the aromatic donor-acceptor interaction, which can be a valuable noncovalent interaction in supramolecular catalyst development.

OXYSTEROLS AND METHODS OF USE THEREOF

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Application of homochiral alkylated organic cages as chiral stationary phases for molecular separations by capillary gas chromatography

Molecular organic cage compounds have attracted considerable attention due to their potential applications in gas storage, catalysis, chemical sensing, molecular separations, etc. In this study, a homochiral pentyl cage compound was synthesized from a condensation reaction of (S,S)-1,2-pentyl-1,2-diaminoethane and 1,3,5-triformylbenzene. The imine-linked pentyl cage diluted with a polysiloxane (OV-1701) was explored as a novel stationary phase for high-resolution gas chromatographic separation of organic compounds. Some positional isomers were baseline separated on the pentyl cage-coated capillary column. In particular, various types of enantiomers including chiral alcohols, esters, ethers and epoxides can be resolved without derivatization on the pentyl cage-coated capillary column. The reproducibility of the pentyl cage-coated capillary column for separation was investigated using nitrochlorobenzene and styrene oxide as analytes. The results indicate that the column has good stability and separation reproducibility after being repeatedly used. This work demonstrates that molecular organic cage compounds could become a novel class of chiral separation media in the near future.