37632-91-0

Basic information

• Product Name: 2'',4'',4-TRINITROBENZANILIDE
• Synonyms: 2'',4'',4-TRINITROBENZANILIDE
• CAS NO: 37632-91-0
• Molecular Formula: C₁₃H₈N₄O₇
• Molecular Weight: 332.227
• Mol File: 37632-91-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 464.6°Cat760mmHg
• Flash Point: 234.8°C
• Appearance: /
• Density: 1.629g/cm³
• Vapor Pressure: 8.22E-09mmHg at 25°C
• Refractive Index: 1.719
• CAS DataBase Reference: 2'',4'',4-TRINITROBENZANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'',4'',4-TRINITROBENZANILIDE(37632-91-0)
• EPA Substance Registry System: 2'',4'',4-TRINITROBENZANILIDE(37632-91-0)

Safety Data

• Hazardous Substances Data: 37632-91-0(Hazardous Substances Data)

Usage

General Description

2'',4'',4-Trinitrobenzanilide, also known as TNB, is a chemical compound commonly used in the synthesis of organic compounds and explosives. It is a yellow crystalline powder that is sparingly soluble in most organic solvents. TNB is highly sensitive to heat, shock, and friction, making it a potential hazard in handling and storage. 2'',4'',4-TRINITROBENZANILIDE is often used in the manufacture of dyes, pharmaceuticals, and rubber chemicals. It is also known for its explosive properties and has been used as an ingredient in the production of various explosives, such as picric acid and trinitroaniline. Additionally, TNB is classified as a potential mutagen and is known to cause skin and eye irritation upon contact.

InChI:InChI=1/C13H8N4O7/c18-13(8-1-3-9(4-2-8)15(19)20)14-11-6-5-10(16(21)22)7-12(11)17(23)24/h1-7H,(H,14,18)

Upstream product

• 62-23-7 4-nitro-benzoic acid 
• 97-02-9 2,4-Dinitroanilin 
• 122-04-3 4-nitro-benzoyl chloride 
• 6333-15-9 4,4'-dinitrobenzanilide 
• 7697-37-2 nitric acid 
• 33490-01-6 4-nitro-N-(2-nitrophenyl)benzamide 
• 3460-11-5 4-nitrobenzanilide 
• 62-53-3 aniline 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 60779-50-2 2',4',4-Triaminobenzanilide 
• 7621-86-5 2-(4-aminophenyl)-5-amino-benzimidazole 
• 91358-43-9 potassium salt of 2',4,4'-trinitrobenzanilide 
• 91358-40-6 terabutylammnonium salt of 2',4,4'-trinitrobenzanilide 
• 29955-49-5 4-Nitro-benzoesaeure-(2,4-dinitro-phenylimid)-chlorid 

Relevant articles and documents

SYNTHESIS OF N-(2,4-DINITROPHENYL)-4-NITROBENZAMIDE (TNBA) USING SOLID ACID CATALYSTS

A method of making N-(2,4-dinitrophenyl)-4-nitrobenzamide from a mixture of 2,4-dinitroaniline, 4-nitrobenzoyl chloride, and solid acid catalyst in an organic solvent, wherein the solid acid catalyst is not soluble in the organic solvent, the solid acid c

Biological evaluation and molecular docking studies of nitro benzamide derivatives with respect to in vitro anti-inflammatory activity

A series of nitro substituted benzamide derivatives were synthesized and evaluated for their potential anti-inflammatory activities in vitro. Firstly, all compounds (1–6) were screened for their inhibitory capacity on LPS induced nitric oxide (NO) production in RAW264.7 macrophages. Compounds 5 and 6 demonstrated significantly high inhibition capacities in a dose-dependent manner with IC50 values of 3.7 and 5.3 μM, respectively. These two compounds were also accompanied by no cytotoxicity at the studied concentrations (max 50 μM) in macrophages. Molecular docking analysis on iNOS revealed that compounds 5 and 6 bind to the enzyme more efficiently compared to other compounds due to having optimum number of nitro groups, orientations and polarizabilities. In addition, 5 and 6 demonstrated distinct regulatory mechanisms for the expression of the iNOS enzyme at the mRNA and protein levels. Specifically, both suppressed expressions of COX-2, IL-1β and TNF-α significantly, at 10 and 20 μM. However, only compound 6 significantly and considerably decreased LPS-induced secretion of IL-1β and TNF-α. These results suggest that compound 6 may be a multi-potent promising lead compound for further optimization in structure and as well as for in vivo validation studies.

HIGH-TEMPERATURE ACYLATION OF AROMATIC AMINES BY AROMATIC CARBOXYLIC ACID CHLORIDES

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