37773-21-0

Basic information

• Product Name: (2-methylphenyl)selanyl
• CAS NO: 37773-21-0
• Molecular Formula: C₇H₈Se
• Molecular Weight: 170.0905
• Mol File: 37773-21-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2-methylphenyl)selanyl(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methylphenyl)selanyl(37773-21-0)
• EPA Substance Registry System: (2-methylphenyl)selanyl(37773-21-0)

Safety Data

• Hazardous Substances Data: 37773-21-0(Hazardous Substances Data)

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 69447-36-5 bis(2-methylphenyl) diselenide 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 69447-36-5 bis(2-methylphenyl) diselenide 
• 88404-78-8 toluene-2-seleninic acid 
• 34009-91-1 4-o-Tolylselanyl-butyric acid 
• 60036-18-2 1-((Z)-2-o-Tolylselanyl-vinyl)-cyclohexylamine 
• 59569-42-5 (Z)-1,1-Dimethyl-3-o-tolylselanyl-allylamine 
• 595580-40-8 (μ-EtOC)(μ-o-MeC6H4Se)Fe2(CO)6 
• 72066-02-5 C₁₆H₁₅⁽²⁾HSe 
• 60036-16-0 (Z)-1,1-Diethyl-3-o-tolylselanyl-allylamine 
• 60036-17-1 1-((Z)-2-o-Tolylselanyl-vinyl)-cyclopentylamine 
• 60036-15-9 (Z)-1-Ethyl-1-methyl-3-o-tolylselanyl-allylamine 
• 72065-41-9 9,9-Bis(o-tolylseleno)bicyclo<4.2.1>nona-2,4,7-triene 
• 82745-55-9 C₁₆H₁₈OSe₂ 
• 97379-49-2 2-Methoxy-monoselenobenzoesaeure-Se-o-tolylester 
• 1657-99-4 (2,4-dinitro-phenyl)-o-tolyl selenide 

Relevant articles and documents

Click Reaction of Selenols with Isocyanates: Rapid Access to Selenocarbamates as Peroxide-Switchable Reservoir of Thiol-Peroxidase-Like Catalysts

Selenols react with isocyanates under mild catalyst-free conditions to generate selenocarbamates in good yield and with high selectivity over potentially competing nucleophilic additions. The methodology enables the incorporation of a wide variety of functional groups providing access to a broad array of densely functionalised selenocarbamates. In the presence of competing heteroatom-centered nucleophiles, isocyanates selectively couple with selenols. Selenocarbamates exhibited thiol-peroxidase-like properties, enabling the reduction of hydrogen peroxide at the expense of thiols, which are converted into the corresponding disulfides. A series of control experiments suggested that the catalytic mechanism proceeds through a pathway, involving a H2O2-promoted transcarbamoylation reaction leading to a thiocarbamate with concomitant releasing of catalytically active selenolate anions. By undergoing peroxide-driven thiol-selenol exchange, selenocarbamates behave as equivalents of selenolate anions with thiol-peroxidase-like activity. (Figure presented.).

Metal-free visible-light induced cyclization/substitution cascade reaction of alkyne-tethered cyclohexadienones and diselenides: Access to 5-hydroxy-3-selenyl-4a,8a-dihydro-2: H -chromen-6(5 H)-ones

A simple and efficient Se-radical triggered cyclization/substitution cascade reaction of alkyne-tethered cyclohexadienones to afford 5-hydroxy-3-selenyl-4a,8a-dihydro-2H-chromen-6(5H)-ones has been developed. This transformation via the 3,5-diselenyl-4a,8a-dihydro-2H-chromen-6(5H)-one intermediate followed by hydrolysis in the presence of CsOAc affords the desired product 3. The resulting products were tested for their in vitro anticancer activity using MTT assay, and compounds 3e and 3q showed potent cancer cell-growth inhibition activities.