37784-10-4

Basic information

• Product Name: L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-, phenyl ester
• CAS NO: 37784-10-4
• Molecular Formula: C16H23NO4S
• Molecular Weight: 325.429
• Mol File: 37784-10-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-, phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-, phenyl ester(37784-10-4)
• EPA Substance Registry System: L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-, phenyl ester(37784-10-4)

Safety Data

• Hazardous Substances Data: 37784-10-4(Hazardous Substances Data)

Upstream product

• 2488-18-8 N-((tert-butyloxy)carbonyl)-L-methionine p-nitrophenyl ester 
• 2488-15-5 N-tert-butoxycarbonyl-L-methionine 
• 108-95-2 phenol 

Relevant articles and documents

Alternative substrates selective for S-adenosylmethionine synthetases from pathogenic bacteria

S-adenosyl-L-methionine (AdoMet) synthetase catalyzes the production of AdoMet, the major biological methyl donor and source of methylene, amino, ribosyl, and aminopropyl groups in the metabolism of all known organism. In addition to these essential functions, AdoMet can also serve as the precursor for two different families of quorum sensing molecules that trigger virulence in Gram-negative human pathogenic bacteria. The enzyme responsible for AdoMet biosynthesis has been cloned, expressed and purified from several of these infectious bacteria. AdoMet synthetase (MAT) from Neisseria meningitidis shows similar kinetic parameters to the previously characterized Escherichia coli enzyme, while the Pseudomonas aeruginosa enzyme has a decreased catalytic efficiency for its MgATP substrate. In contrast, the more distantly related MAT from Campylobacter jejuni has an altered quaternary structure and possesses a higher catalytic turnover than the more closely related family members. Methionine analogs have been examined to delineate the substrate specificity of these enzyme forms, and several alternative substrates have been identified with the potential to block quorum sensing while still serving as precursors for essential methyl donation and radical generation reactions.

ACTIVATION OF A CARBOXY GROUP BY DIALKYL PYROCARBONATES. SYNTHESIS OF SYMMETRICAL ANHYDRIDES AND ARYL ESTERS OF N-PROTECTED AMINO ACIDS USING DI-tert-BUTYL PYROCARBONATE AS CONDENSING REAGENT

It has been shown that di-tert-butyl pyrocarbonate can be used as a condensing reagent in the production of anhydrides and some aryl esters of carboxylic acids.The synthesis of anhydrides and of phenyl, p-nitrophenyl, β-naphtyl, and quinolin-8-yl esters of N-protected amino acids is described.