2488-18-8 Usage
General Description
BOC-MET-ONP is a chemical compound used in the synthesis of peptides. It consists of a BOC-protected methionine amino acid linked to an o-nitrophenyl (ONP) ester group. The BOC-protected methionine provides a temporary protective group for the amino acid, allowing for selective deprotection during peptide synthesis. The ONP group serves as a chromophore for photometric detection and quantification during the peptide synthesis process. BOC-MET-ONP is commonly used as a building block in solid-phase peptide synthesis for the production of peptide-based drugs, research tools, and biochemical probes.
Check Digit Verification of cas no
The CAS Registry Mumber 2488-18-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2488-18:
(6*2)+(5*4)+(4*8)+(3*8)+(2*1)+(1*8)=98
98 % 10 = 8
So 2488-18-8 is a valid CAS Registry Number.
2488-18-8Relevant articles and documents
Kinetic Studies in Peptide Chemistry. Coupling, Racemization, and Evaluation of Methods Useful for Shortening Coupling Time
Kovacs, J.,Holleran, E. M.,Hui, K. Y.
, p. 1060 - 1065 (2007/10/02)
Kinetic studies were carried out on N-protected methionine and glycylmethionine active esters to determine the racemization rate constants with triethylamine and the coupling rate constants with valine methyl ester.In contrast to cysteine dipeptide active esters, which racemize through an enolization mechanism, the methionine dipeptide active esters racemize through the usual 5(4H)-oxazolone route.The role of sulfur in the side chain is discussed.The time required for coupling a given percentage (e.g., 99 percent) of the amine component can be significantly reduced by using an excess of the active ester.This method is evaluated quantitatively for second-order kinetics.
