37842-92-5

Basic information

• Product Name: Benzamide, 4-cyano-N-hydroxy- (9CI)
• Synonyms: Benzamide, 4-cyano-N-hydroxy- (9CI);4-Cyano-N-hydroxybenzamide
• CAS NO: 37842-92-5
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.14544
• Product Categories: AMIDE
• Mol File: 37842-92-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzamide, 4-cyano-N-hydroxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-cyano-N-hydroxy- (9CI)(37842-92-5)
• EPA Substance Registry System: Benzamide, 4-cyano-N-hydroxy- (9CI)(37842-92-5)

Safety Data

• Hazardous Substances Data: 37842-92-5(Hazardous Substances Data)

Upstream product

• 105-07-7 4-cyanobenzaldehyde 
• 619-65-8 4-cyanobenzoic Acid 
• 87235-62-9 N-(4-cyanobenzoyl)imidazole 
• 99300-38-6 4-cyanobenzoic acid N-hydroxysuccinimide ester 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 1129-35-7 4-cyanobenzoic acid methyl ester 

Downstream Products

• 857772-73-7 N-(4-cyano-benzoyl)-O-(4-cyano-phenylcarbamoyl)-hydroxylamine 
• 1610376-31-2 4-cyano-N-(pivaloyloxy)-2-((triisopropylsilyl)ethynyl)benzamide 
• 80-05-7 BPA 
• 873-74-5 4-Aminobenzonitrile 

Relevant articles and documents

Synthesis of sulfimides and N-Allyl-N-(thio)amides by Ru(II)catalyzed nitrene transfer reactions of N-acyloxyamides

The N-acyloxyamides were employed as effective N-acyl nitrene precursors in reactions with thioethers under the catalysis of a commercially available Ru(II) complex, from which a variety of sulfimides were synthesized efficiently and mildly. If an allyl group is contained in the thioether precursor, the [2,3]-sigmatropic rearrangement of the sulfimide occurs simultaneously and the N-allyl-N-(thio)amides were obtained as the final products. Preliminary mechanistic studies indicated that the Ru-nitrenoid species should be a key intermediate in the transformation.

Straightforward synthesis of 4,5-bifunctionalized 1,2-oxazinanes via Lewis acid promoted regio- and stereo-selective nucleophilic ring-opening of 3,6-dihydro-1,2-oxazine oxides

Functionalized 1,2-oxazinanes are interesting and valuable heterocycles with potential applications in synthetic and medicinal chemistry. A straightforward strategy for quick access to unprecedented trans-4-hydroxyl-5-azido/cyano/amino 1,2-oxazinanes are developed: N-COR 3,6-dihydro- 1,2-oxazine oxides are prepared with ease from related dihydro- 1,2-oxazines and opened by nucleophiles TMSN3, TMSCN and aryl/alkyl amines. Appropriate Lewis acid catalysts are found playing a vital role for both reaction rate and regioselectivity. The N-COR group can be removed under mild conditions to provide highly desirable NH 1,2-oxazinanes inaccessible via previous methods.

One-pot synthesis of primary amines from carboxylic acids through rearrangement of in situ generated hydroxamic acid derivatives

A one-pot synthesis of primary amines from carboxylic acids through a Lossen rearrangement of hydroxamic acid derivatives, which were in situ generated by the reaction of carboxylic acids with O-trimethylsilylhydroxylamine (NH2OTMS) and carbonyl diimidazole (CDI, 1.5 equiv) in dimethyl sulfoxide at room temperature, has been achieved. This one-pot method could be applied to various carboxylic acids such as aromatic, heteroaromatic, aliphatic, and optically active substrates.