3791-76-2

Basic information

• Product Name: 1-(2-HYDROXY-4,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPAN-1-ONE
• Synonyms: 1-(2-HYDROXY-4,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPAN-1-ONE
• CAS NO: 3791-76-2
• Molecular Formula: C₁₇H₁₈O₄
• Molecular Weight: 286.32
• Mol File: 3791-76-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 479.1°Cat760mmHg
• Flash Point: 175.8°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 8.41E-10mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 1-(2-HYDROXY-4,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-HYDROXY-4,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPAN-1-ONE(3791-76-2)
• EPA Substance Registry System: 1-(2-HYDROXY-4,6-DIMETHOXY-PHENYL)-3-PHENYL-PROPAN-1-ONE(3791-76-2)

Safety Data

• Hazardous Substances Data: 3791-76-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 20, p. 1885, 1990 DOI: 10.1080/00397919008053115

InChI:InChI=1/C17H18O4/c1-20-13-10-15(19)17(16(11-13)21-2)14(18)9-8-12-6-4-3-5-7-12/h3-7,10-11,19H,8-9H2,1-2H3

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Downstream Products

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Relevant articles and documents

Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors

In a continuing study for discovering urease inhibitors based on flavonoids, nineteen reductive derivatives of flavonoids were synthesized and evaluated against Helicobacter pylori urease. Analysis of structure-activity relationship disclosed that 4-deoxy analogues are more potent than other reductive products. Out of them, 4′,7,8-trihydroxyl-2-isoflavene (13) was found to be the most active with IC50 of 0.85 μM, being over 20-fold more potent than the commercial available urease inhibitor, acetohydroxamic acid (AHA). Kinetics study revealed that 13 is a competitive inhibitor of H. pylori urease with a Ki value of 0.641 μM, which is well matched with the results of molecular docking. Biological evaluation and mechanism study of 13 suggest that it is a good candidate for discovering novel anti-gastritis and anti-gastric ulcer agent.

Pd-C/ammonium formate: A selective catalyst for the hydrogenation of chalcones to dihydrochalcones

Pd-C/ammonium formate is a highly efficient catalyst for the selective hydrogenation of chalcones to dihydrochalcones (DHCs). The reaction proceeds under mild conditions and the Pd-C catalyst is recovered without loss of activity.

Facile reduction of chalcones to dihydrochalcones with NaBH4/Ni2+ system

Chalcones have been found to undergo facile reduction on treatment with sodium borohydride-nickel chloride system in dioxan-methanol medium to afford dihydrochalcones.