75291-74-6

Basic information

• Product Name: 5-HYDROXY-7-METHOXYFLAVANONE
• Synonyms: PINOCEMBRIN-7-METHYL ETHER;7-METHOXY-5-HYDROXYFLAVANONE;PINOCEMBRIN-7-METHYLETHER(RG);5-HYDROXY-7-METHOXYFLAVANONE 97%;(RS)-2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one
• CAS NO: 75291-74-6
• Molecular Formula: C₁₆H₁₄O₄
• Molecular Weight: 270.28
• EINECS: 207-548-1
• Mol File: 75291-74-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-HYDROXY-7-METHOXYFLAVANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXY-7-METHOXYFLAVANONE(75291-74-6)
• EPA Substance Registry System: 5-HYDROXY-7-METHOXYFLAVANONE(75291-74-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 75291-74-6(Hazardous Substances Data)

Upstream product

• 480-39-7 pinocembrin 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 1775-97-9 flavokawain B 
• 520-28-5 tectochrysine 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 1036-72-2 5,7-dimethoxyflavone 
• 10035-10-6 hydrogen bromide 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 60-29-7 diethyl ether 
• 186581-53-3 diazomethane 
• 18956-15-5 pinostrobin chalcone 

Downstream Products

• 1220680-30-7 7-methoxy-5-(prop-2-enyloxy)flavanone 
• 1220680-32-9 5-hydroxy-7-methoxy-6-(prop-2-enyl)flavanone 
• 1227479-72-2 (5-hydroxy-7-methoxyflavonone)oxime 
• 29646-98-8 pinostrobin Acetate 
• 1220680-24-9 7-methoxy-5-(3-methylbut-2-enyloxy)flavanone 
• 3791-76-2 2’-hydroxy-4’,6’-dimethoxydihydrochalcone 
• 18956-15-5 pinostrobin chalcone 

Relevant articles and documents

Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora

Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC50 values of 0.014 and 0.23 μM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC50 values of 4.04 and 2.32 μM, respectively.

Variations in the chemical shift of the 5-hydroxyl proton of 7-o-prenylated flavanones

In 1H nmr examination of 6- or 8-prenylated flavanone 7-methyl and 7-prenyl ethers, the signals of hydrogen-bonded hydroxyl proton appeared in relatively narrow region. Relatively large solvent effect was observed on the signal of 6-prenylflavanone 7-methyl and 7-prenyl ethers.

Constituents of Boesenbergia pandurata ( syn. Kaempferia pandurata) : Isolation, Crystal Structure and Synthesis of (+/-)-Boesenbergin A

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