37957-76-9

Basic information

• Product Name: 3-dimethylaminomethylene-1-methyl-5-phenyl-7-trifluoromethyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
• CAS NO: 37957-76-9
• Molecular Weight: 389.377
• Mol File: 37957-76-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-dimethylaminomethylene-1-methyl-5-phenyl-7-trifluoromethyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-dimethylaminomethylene-1-methyl-5-phenyl-7-trifluoromethyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione(37957-76-9)
• EPA Substance Registry System: 3-dimethylaminomethylene-1-methyl-5-phenyl-7-trifluoromethyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione(37957-76-9)

Safety Data

• Hazardous Substances Data: 37957-76-9(Hazardous Substances Data)

Upstream product

• 61352-54-3 1-methyl-7-trifluoromethyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 
• 35203-49-7 N¹-methyl-4-(trifluoromethyl)benzene-1,2-diamine 
• 20200-22-0 α,α,α-Trifluoro-N-methyl-6-nitro-p-toluidine 

Relevant articles and documents

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

The discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly is described. Synthesis of analogs of the 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione hit established structure-activity relationships. Replacement of the enamine functionality of the hit series with either an imidazole or a pyrazole ring led to compounds that inhibited both capsid assembly and reverse transcriptase. Optimization of the bicyclic benzodiazepine scaffold to include a 3-phenyl substituent led to lead compound 48, a pure capsid assembly inhibitor with improved antiviral activity.