38002-45-8 Usage
Description
3-Bromo-1-(trimethylsilyl)-1-propyne, also known as a propargylating agent, is a clear colorless to pale yellow liquid with significant chemical properties. It is characterized by its reactivity and selectivity in various chemical reactions, making it a valuable compound in the field of organic chemistry.
Uses
Used in Pharmaceutical Industry:
3-Bromo-1-(trimethylsilyl)-1-propyne is used as a reagent for the alkylation of dianion of β-keto esters at γ-carbon. This application is crucial in the synthesis of various pharmaceutical compounds, as it allows for the creation of complex molecular structures with specific properties.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-Bromo-1-(trimethylsilyl)-1-propyne is used in the preparation of tetrahydroisoquinoline-3-carboxylic acid derivatives. These derivatives are important intermediates in the synthesis of various organic compounds, including pharmaceuticals and other specialty chemicals.
Used in Organic Chemistry Research:
3-Bromo-1-(trimethylsilyl)-1-propyne is employed in the preparation of terminal conjugated enynes and allenic alcohols. These compounds are valuable in organic chemistry research due to their unique structures and potential applications in the development of new materials and pharmaceuticals.
General Description:
3-Bromo-1-(trimethylsilyl)-1-propyne is reported as a propargylating agent, which is a type of reagent used in organic chemistry to introduce a propargyl group (a triple-bonded carbon chain) into a molecule. The selective reaction of 3-bromo-1-(trimethylsilyl)-1-propyne with α-keto ester using indium metal has been studied, demonstrating its potential in various chemical reactions and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 38002-45-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,0,0 and 2 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 38002-45:
(7*3)+(6*8)+(5*0)+(4*0)+(3*2)+(2*4)+(1*5)=88
88 % 10 = 8
So 38002-45-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H11BrSi/c1-8(2,3)6-4-5-7/h5H2,1-3H3
38002-45-8Relevant articles and documents
Kinetically Controlled Radical Addition/Elimination Cascade: From Alkynyl Aziridine to Fluorinated Allenes
Song, Tingting,Zhu, Lei,Li, Haoyu,Tung, Chen-Ho,Lan, Yu,Xu, Zhenghu
, p. 2419 - 2424 (2020)
A kinetically controlled radical addition/elimination reaction generating fluorinated allenes was developed. This strategy offers a route to a facile synthesis of diverse trifluoromethyl, difluoromethylene, and perfluoroalkyl functionalized allenes from readily available fluoroalkyl halides and alkynyl aziridines under visible-light irradiation. Density functional theory calculation of this radical clock type of reaction revealed a kinetically controlled C-N bond cleavage overcoming the alternative thermodynamically controlled C-C bond cleavage process.
Low-valent dialkoxytitanium(ii): a useful tool for the synthesis of functionalized seven-membered ring compounds
Bodinier, Florent,Sanogo, Youssouf,Ardisson, Janick,Lannou, Marie-Isabelle,Sorin, Geoffroy
supporting information, p. 3603 - 3606 (2021/04/14)
Herein, we describe unprecedented access to all-carbon or heterocyclic seven-membered ring frameworks from 1,8-ene-ynes promoted by inexpensive low-valent titanium(ii) species, readily available from Ti(OiPr)4and Grignard reagent. A broad range of cycloheptane, azepane or oxepane derivatives has been obtained (19 examples) with moderate to good yields and an excellent selectivity (up to 95/5 d.r.).
Direct Access to Allenylphosphine Oxides via a Metal Free Coupling of Propargylic Substrates with P(O)H Compounds
Yang, Chun-Hua,Fan, Huihui,Li, Huimin,Hou, Shenyin,Sun, Xiangkun,Luo, Donghao,Zhang, Yinchao,Yang, Zhantao,Chang, Junbiao
, p. 9438 - 9441 (2019/11/20)
A direct and convenient approach for the coupling of propargylic substrates with diphenylphosphine oxide in the presence of Tf2O and 2,6-lutidine has been developed. The method provides a general approach for the construction of attractive allenylphosphoryl skeletons with high atom and step economy under metal free conditions.
