38030-57-8 Usage
Description
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxo-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid is a complex organic compound with a unique molecular structure characterized by its multiple double bonds and methyl groups. It is derived from all-trans-Retinoic Acid, a significant metabolite and a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxo-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid is an orange solid with potential applications in various fields due to its chemical properties and interactions with specific receptors.
Uses
Used in Pharmaceutical Industry:
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxo-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid is used as a therapeutic agent for treating various health conditions. Its interaction with the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) makes it a promising candidate for the development of drugs targeting these receptors, potentially leading to treatments for a range of diseases.
Used in Cosmetic Industry:
In the cosmetic industry, (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxo-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid is used as an active ingredient in skincare products. Its ability to modulate retinoic acid receptors may contribute to anti-aging effects, skin regeneration, and improvement of skin texture.
Used in Research and Development:
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxo-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid is also utilized in research and development for its potential applications in understanding the mechanisms of retinoic acid receptors and their role in various biological processes. It can serve as a valuable tool in the development of new drugs and therapies targeting these receptors.
Used in Nutritional Supplements:
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxo-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid may be used as an ingredient in nutritional supplements, particularly those aimed at promoting skin health and overall well-being. Its interaction with retinoic acid receptors could provide benefits related to skin health and cellular regeneration.
Check Digit Verification of cas no
The CAS Registry Mumber 38030-57-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,0,3 and 0 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 38030-57:
(7*3)+(6*8)+(5*0)+(4*3)+(3*0)+(2*5)+(1*7)=98
98 % 10 = 8
So 38030-57-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13+
38030-57-8Relevant articles and documents
AN IMPROVED PROCESS FOR THE PREPARATION OF 4-OXOISOTRETINOIN
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Page/Page column 12-13, (2022/02/28)
The present invention relates to an improved process for the preparation of 4-Oxoisotretinoin and purification process of 4-Oxoisotretinoin (I) and crystalline 5 form of 4-Oxoisotretinoin (I).
A sensitive and specific method for measurement of multiple retinoids in human serum with UHPLC-MS/MS
Arnold, Samuel L. M.,Amory, John K.,Walsh, Thomas J.,Isoherranen, Nina
experimental part, p. 587 - 598 (2012/05/31)
Retinol (vitamin A) circulates at 1-4 μM concentration and is easily measured in serum. However, retinol is biologically inactive. Its metabolite, retinoic acid (RA), is believed to be responsible for biological effects of vitamin A, and hence the measurement of retinol concentrations is of limited value. A UHPLC-MS/MS method using isotope-labeled internal standards was developed and validated for quantitative analysis of endogenous RA isomers and metabolites. The method was used to measure retinoids in serum samples from 20 healthy men. In the fed state, the measured concentrations were 3.1 ± 0.2 nM for at RA, 0.1 ± 0.02 nM for 9-cisRA, 5.3 ± 1.3 nM for 13-cisRA, 0.4 ± 0.4 nM for 9,13-dicisRA, and 17.2 ± 6.8 nM for 4oxo-13-cisRA. The concentrations of the retinoids were not significantly different when measured after an overnight fast (3.0 ± 0.1 nM for atRA, 0.09 ± 0.01nM for 9-cisRA, 3.9 ± 0.2 nM for 13-cisRA, 0.3 ± 0.1 nM for 9,13-dicisRA, and 11.9 ± 1.6 nM for 4oxo-13-cisRA). 11-cisRA and 4OH-RA were not detected in human serum. The high sensitivity of the MS/MS method combined with the UHPLC separation power allowed detection of endogenous 9-cis RA and 4oxo-atRA for the first time in human serum. Copyright
All-Trans-Retinol: All-Trans-13,14-Dihydroretinol Saturase and Methods of Its Use
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Page/Page column 2; 27; 29; 31; Sheet 14/24; 24/24, (2008/12/08)
Compositions of all-trans-retinol: all-trans-13,14-dihydroretinal saturase and methods of use thereof are provided.