3806-59-5

Basic information

• Product Name: 1,3-CYCLOOCTADIENE
• Synonyms: 1,3-CYCLOOCTADIENE;CIS, CIS-1,3-CYCLOOCTADIENE;CYCLOOCTADIENE-1,3;1,3-Cyclooctadiene, (Z,Z)-;CIS CIS-1 3-CYCLOOCTADIENE 95%;(1Z,3Z)-1,3-Cyclooctadiene;1,3-COD
• CAS NO: 3806-59-5
• Molecular Formula: C₈H₁₂
• Molecular Weight: 108.18
• EINECS: 216-929-1
• Product Categories: Alkenes;Cyclic;Organic Building Blocks
• Mol File: 3806-59-5.mol
• Article Data: 47

Chemical Properties

• Melting Point: −53-−51 °C(lit.)
• Boiling Point: 55 °C34 mm Hg(lit.)
• Flash Point: 76 °F
• Appearance: /
• Density: 0.873 g/mL at 20 °C(lit.)
• Refractive Index: n20/D 1.494
• Storage Temp.: 2-8°C
• BRN: 1901033
• CAS DataBase Reference: 1,3-CYCLOOCTADIENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-CYCLOOCTADIENE(3806-59-5)
• EPA Substance Registry System: 1,3-CYCLOOCTADIENE(3806-59-5)

Safety Data

• Hazard Codes: T
• Statements: 10-36/38-65-36/37/38-25
• Safety Statements: 26-45
• RIDADR: UN 2520 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 3806-59-5(Hazardous Substances Data)

Usage

Description

1,3-Cyclooctadiene is an organic compound with the molecular formula C8H12. It is a diene, meaning it contains two carbon-carbon double bonds, and is known for its ability to undergo cyclization reactions. 1,3-CYCLOOCTADIENE is involved in the photosensitized cyclization process, where it isomerizes to its cis, trans isomer before undergoing cyclization to form bicyclo[4.2.0]oct-7-ene.

Uses

1,3-Cyclooctadiene is used as a chemical intermediate in the synthesis of various organic compounds, particularly in the production of bicyclo[4.2.0]oct-7-ene through the photosensitized cyclization process. This reaction is significant in organic chemistry as it demonstrates the isomerization and cyclization of dienes, which can be applied to the synthesis of other complex organic molecules.
Used in Chemical Synthesis Industry:
1,3-Cyclooctadiene is used as a key reactant for the synthesis of complex organic molecules, such as bicyclo[4.2.0]oct-7-ene, which can have potential applications in various fields, including pharmaceuticals, materials science, and specialty chemicals. Its ability to undergo cyclization reactions makes it a valuable building block for the development of novel compounds with unique properties and potential applications.

Synthesis Reference(s)

Journal of the American Chemical Society, 83, p. 2954, 1961 DOI: 10.1021/ja01474a039

InChI:InChI=1/C8H12/c1-2-4-6-8-7-5-3-1/h1-4H,5-8H2/b3-1-,4-2-

Upstream product

• 1552-12-1 1,5-cis,cis-cyclooctadiene 
• 106-99-0 buta-1,3-diene 
• 1295-35-8 bis(1,5-cyclooctadiene)nickel ⁽⁰⁾ 
• 3064-56-0 diphenylphosphinoacetic acid 
• 3806-60-8 (1E,3Z)-1,3-cyclooctadiene 
• 109-99-9 tetrahydrofuran 
• 558-37-2 tert-butylethylene 
• 292-64-8 Cyclooctan 
• 16065-88-6 palladium (II) ion 
• 502-49-8 cycloactanone 
• 931-88-4 1,2-cyclooctene 
• 629-20-9 1,3,5,7-cyclooctatetraene 
• 3806-82-4 cis-bicyclo[4.2.0]oct-7-ene 
• 26601-20-7 1,2-dichlorocyclooctane 

Downstream Products

• 931-88-4 cis-Cyclooctene 
• 5549-09-7 bicyclo[3.3.0]oct-2-ene 
• 87291-52-9 4-Ethylbicyclo<3.3.0>oct-2-en 
• 1700-10-3 cyclooctadienyl anion 
• 15052-35-4 10,10-diphenyl-cis-9-thiabicyclo<6.2.0>-2-decene 
• 10316-54-8 2-phenyl-hexahydro-5,10-etheno-[1,2,4]triazolo[1,2-a][1,2]diazocine-1,3-dione 
• 7302-00-3 (E)-1,3-diphenyl-1-butene 
• 1700-10-3 (E,Z)-1,3-cyclooctadiene 
• 81368-86-7 trihydrido(cycloocta-1,5-diene)bis(triphenylphosphine)rhenium 
• 174850-49-8 anti-(9-phenyl-9-phosphabicyclo[6.1.0]nona-3-ene)pentacarbonyltungsten 
• 77074-91-0 3-Phenyl-4-phenylcarbamoyl-2-oxa-3-azabicyclo<6.3.0>undec-10-ene 

Relevant articles and documents

The Ru(η6-naphthalene)(η4-1,5-cyclooctadiene)/acetonitrile system as a homogeneous catalytic precursor for the fast isomerization of 1,5-cyclooctadiene and 1-hexene

1,5-Cyclooctadiene and 1-hexene undergo isomerization to 1,3-cyclooctadiene and (E)-/(Z)-2-hexene, respectively, with high turnover number in the presence of the complex Ru(η6-naphthalene)(η4-1,5-cyclooctadiene) and acetonitrile.This high catalytic activity is observed only using acetonitrile as co-catalyst.A possible reaction mechanism, based on results from an 1H and 2H NMR study of the isomerization, is presented.

-

-

Synthesis and reactivity of a masked PSiP pincer supported nickel hydride

Tridentate PSiP pincer ligands featuring two phosphine donors and an anionic Si donor have attracted considerable attention in recent years. Here, we report the synthesis of the η3-cyclooctenyl complex, (PhPSiP)Ni(η3-cyclooctenyl) (1; PhPSiP = Si(Me)(2-PPh2-C6H4)2) through the reaction of Ni(COD)2 with PhPSiHP (PhPSiHP = HSi(Me)(2-PPh2-C6H4)2). We propose, that as a result of β-hydride elimination of 1,3-COD, 1 can act as a synthetic equivalent for (PhPSiP)NiH. The reaction of 1 with a variety of different reagents including another equivalent of PhPSiHP to form (PhPSiP)2Ni (2), 1,3-COD and H2, PPh3 to form the Ni(0) species (PhPSiHP)Ni(PPh3) (3) and 1,3-COD and 2,6-lutidine·HCl to generate (PhPSiP)NiCl (4), 1,3-COD and H2 are in agreement with this hypothesis. In addition, in the reaction of 1 with BH3·THF, (PhPSiP)Ni(κ2-BH4) (5) was observed but could not be isolated. This reaction presumably proceeds via (PhPSiP)NiH. This is supported by the observation that the reaction of (CyPSiP)NiH (CyPSiP = Si(Me)(2-PCy2-C6H4)2) with BH3·THF formed (CyPSiP)Ni(κ2-BH4) (6). Catalytic reactions such as alkene isomerization and CO2 reduction using 1 as precatalyst are also consistent with a nickel hydride being accessible. Compounds 1, 2 and 6 were characterized by X-ray crystallography.

Highly active and recyclable heterogeneous iridium pincer catalysts for transfer dehydrogenation of alkanes

Pincer-ligated iridium complexes have proven to be highly effective catalysts for the dehydrogenation and transfer-dehydrogenation of alkanes. Immobilization onto a solid support offers significant potential advantages in the application of such catalysts particularly with respect to catalyst separation and recycling. We describe three approaches toward such immobilization: (i) covalent attachment to a Merrifield resin, (ii) covalent bonding to silica via a pendant alkoxysilane group, and (iii) adsorption on γ-alumina (γ-Al2O3), through basic functional groups on the para-position of the pincer ligand. The simplest of these approaches, adsorption on γ-Al2O3, is also found to be the most effective, yielding catalysts that are robust, recyclable, and comparable to or even more active than the corresponding species in solution. Spectroscopic evidence (NMR, IR) and studies of catalytic activity support the hypothesis that binding occurs at the para-substituent and that this has only a relatively subtle and indirect influence on catalytic behavior.