38129-37-2 Usage
Description
Bicozamycin, also known as Bicyclomycin, is a commercially significant azabicyclic antibiotic that was first isolated from Streptomyces sapporonensis in 1972. It is characterized by its selective activity against Gram-negative bacteria, which is a rare trait among Streptomyces metabolites. Bicozamycin functions by inhibiting the Rho protein of E. coli, making it a valuable compound in the field of antibiotics.
Uses
Used in Pharmaceutical Industry:
Bicozamycin is used as an antibiotic for targeting and treating bacterial infections, particularly those caused by Gram-negative bacteria. Its unique mode of action, which involves the inhibition of the Rho protein in E. coli, makes it a potentially effective agent in combating antibiotic-resistant strains.
Used in Research and Development:
In the field of microbiology and pharmaceutical research, Bicozamycin serves as a valuable tool for studying the mechanisms of bacterial transcription and the role of the Rho protein in bacterial growth and replication. This can lead to the development of new antibiotics and a better understanding of bacterial resistance.
Used in Drug Resistance Studies:
Bicozamycin's selective activity against Gram-negative bacteria makes it an important compound in the study of drug resistance. It can be used to investigate the development of resistance in these bacteria and to develop strategies to overcome resistance, ultimately contributing to the development of more effective antibiotics.
Check Digit Verification of cas no
The CAS Registry Mumber 38129-37-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,1,2 and 9 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 38129-37:
(7*3)+(6*8)+(5*1)+(4*2)+(3*9)+(2*3)+(1*7)=122
122 % 10 = 2
So 38129-37-2 is a valid CAS Registry Number.
38129-37-2Relevant articles and documents
The biosynthesis of the Streptomyces antibiotic bicyclomycin
Bradley, Emma L.,Herbert, Richard B.,Lawrie, Kenneth W.M.,Khan, Jeffrey A.,Moody, Claire M.,Young, Douglas W.
, p. 6935 - 6938 (1996)
Bicyclomycin 5 is biosynthesized in Streptomyces sapporonensis from L-leucine 2 and L-isoleucine 1 by way of the naturally occurring diketopiperazine 3 and dihydrobicyclomycin 4. The mode of incorporation of (2S,4R)-[5,5,5-2H3]leucine into 5 (and 4) shows that the entry of hydroxy group at C-2' occurs with unusual inversion of configuration. The results of inhibition studies permit a useful working hypothesis to be advanced for bicyclomycin biosynthesis.
THE CHIRAL SYNTHESIS OF BICYCLOMYCIN
Yoshimura, Juji,Yamaura, Masanori,Suzuki, Tsuneji,Hashimoto, Hironobu
, p. 2157 - 2158 (2007/10/02)
The optically active bicyclomycin was succesfully synthesized in 17 steps from N,N'-diacetyl-anhydroglycine.
TOTAL SYNTHESIS OF BICYCLOMYCIN
Nakatsuka, Shin-ichi,Yamada, Kozi,Yoshida, Kumi,Asano, Osamu,Murakami, Yoshihiro,Goto, Toshio
, p. 5627 - 5630 (2007/10/02)
Total synthesis of (+/-)-bicyclomycin was achieved in 19 steps starting from diketopyperazine.
