848567-80-6Relevant articles and documents
Development of a technique to determine bicyclomycin-rho binding and stoichiometry by isothermal titration calorimetry and mass spectrometry
Brogan, Andrew P.,Widger, William R.,Bensadek, Dalila,Riba-Garcia, Isabel,Gaskell, Simon J.,Kohn, Harold
, p. 2741 - 2751 (2005)
Bicyclomycin (1) is the only natural product inhibitor of the transcription termination factor rho. Rho is a hexameric helicase that terminates nascent RNA transcripts utilizing ATP hydrolysis and is an essential protein for many bacteria. The paucity of
