38155-45-2

Basic information

• Product Name: L-Leucine, L-phenylalanyl-, methyl ester, monohydrochloride
• CAS NO: 38155-45-2
• Molecular Formula: C16H24N2O3.ClH
• Molecular Weight: 328.839
• Mol File: 38155-45-2.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: L-Leucine, L-phenylalanyl-, methyl ester, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, L-phenylalanyl-, methyl ester, monohydrochloride(38155-45-2)
• EPA Substance Registry System: L-Leucine, L-phenylalanyl-, methyl ester, monohydrochloride(38155-45-2)

Safety Data

• Hazardous Substances Data: 38155-45-2(Hazardous Substances Data)

Upstream product

• 84759-67-1 CBZ-ΔPhe-L-Leu-OMe 
• 4192-12-5 Boc-Phe-OH*DCHA 
• 6322-53-8 leucine methyl ester hydrochloride 
• 64152-76-7 Boc-Phe-Leu-OMe 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 63-91-2 L-phenylalanine 
• 61-90-5 L-leucine 
• 72015-61-3 (Z)-2-benzyloxycarbonylaminocinnamic acid 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 72015-61-3 2-benzyloxycarboxamidocinnamic acid 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 1161-13-3 N-Cbz-L-Phe 
• 2666-93-5 (S)-Leu-OMe 
• 188783-11-1 N-[N-(2-benzoyl-2-ethoxycarbonylvinyl-1)-L-3-phenylalanyl]-L-leucine methyl ester 

Downstream Products

• 1365292-44-9 L-isoseryl-L-phenylalanyl-L-leucine methyl ester hydrochloride 
• 96914-81-7 C₂₁H₃₄N₃O₆P 
• 96914-78-2 C₁₉H₃₂N₃O₅P 
• 145763-51-5 (S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester 
• 145763-41-3 N-benzyloxycarbonyl-O-tosyl-(Z)dehydrotyrosyl-(R)alanyl-glycyl-(S)phenylalanyl-(S)leucine methyl ester 
• 83892-15-3 (R)alanyl-glycyl-(S)phenylalanyl-(S)leucine methyl ester 
• 85541-31-7 Glycyl-glycyl-(S)-phenylalanyl-(S)-leucinmethylesterhydrochlorid 
• 120915-53-9 N--L-leucine 
• 356789-15-6 (trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine 
• 356789-14-5 (trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine methyl ester 
• 578764-50-8 (S)-4-Methyl-2-[(S)-3-phenyl-2-(2-{(2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-[(S)-2-benzyloxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-tetrahydro-pyran-2-yl}-acetylamino)-propionylamino]-pentanoic acid methyl ester 

Relevant articles and documents

Peptide-Catalyzed Fragment Couplings that Form Axially Chiral Non-C2-Symmetric Biaryls

We have demonstrated that small, modular, tetrameric peptides featuring the Lewis-basic residue β-dimethylaminoalanine (Dmaa) are capable of atroposelectively coupling naphthols and ester-bearing quinones to yield non-C2-symmetric BINOL-type scaffolds with good yields and enantioselectivity. The study culminates in the asymmetric synthesis of backbone-substituted scaffolds similar to 3,3′-disubstituted BINOLs, such as (R)-TRIP, with good (94:6 e.r.) to excellent (>99.9:0.1 e.r.) enantioselectivity after recrystallization, and a diastereoselective net arylation of the minimally modified nonsteroidal anti-inflammatory drug (NSAID) naproxen.

Antimicrobial toxicity studies of ionic liquids leading to a 'hit' MRSA selective antibacterial imidazolium salt

Imidazolium salts can be classed as surfactants, detergents, ionic liquids, reagents, catalysts or solvents. A study of the toxicity and ecotoxicity of these salts yields valuable information for their use as pharmaceuticals as well as impact on the environment. Our approach to screen a series of chiral imidazolium salts for toxicity to bacteria and fungi, including clinical pathogen strains, has led to the identification of a 'hit' MRSA selective antimicrobial compound. Preliminary structure-activity-relationship (SAR) information (required position of l-phenylalanine and l-valine group) is also elucidated within this first generation of compounds. Conversely, most of the imidazolium salts were nontoxic (IC95 > 2 mM) to the 12 fungi strains and 8 bacteria strains screened, and we propose that they are suitable candidates for 'green chemistry' applications. Ecotoxicity studies (Biodegradation ISO 14593 'CO2 Headspace Test') of two bromide ionic liquids containing l-phenylalanine residues indicate that these ionic liquids passed the test (>60% in 28 days) and classed as readily biodegradable.

Efficient synthesis of 2,5-diketopiperazines using microwave assisted heating

In this study a general, efficient and environmentally benign solution phase synthesis of 2,5-diketopiperazines (DKPs) using microwave assisted heating in water is described. A series of 11 structurally different DKPs have been synthesized from dipeptide methyl esters. A range of common laboratory solvents have been tested as well as different reaction times and temperatures. Both classic thermal and microwave assisted heating have been investigated. Microwave assisted heating for 10 min using water as solvent proved, by far, to be the most efficient method of cyclization giving moderate to excellent yields (63-97%) of DKPs. In contrast to other published procedures, this method seems independent of the amino acid sequence.