381725-49-1 Usage
Description
6'-Methoxy-2,3'-bipyridine is an organic compound with the molecular formula C11H9NO. It is characterized by the presence of a methoxy group at the 6' position and a bipyridine structure, which consists of two pyridine rings connected at the 2' and 3' positions. 6'-Methoxy-2,3'-bipyridine is known for its potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
6'-Methoxy-2,3'-bipyridine is used as a reagent for the synthesis of AMPA receptor antagonists, which are crucial in the treatment of neurological diseases. These diseases often involve dysfunction of glutamatergic neurotransmission, and the antagonists help regulate the overstimulation of the receptors, providing relief from the symptoms.
6'-Methoxy-2,3'-bipyridine is also used as a key intermediate in the development of new drugs targeting neurological disorders. Its unique structure allows for further chemical modifications, enabling the creation of more potent and selective compounds with improved pharmacological properties.
Used in Chemical Synthesis:
In the field of chemical synthesis, 6'-Methoxy-2,3'-bipyridine serves as a valuable building block for the creation of various complex organic molecules. Its bipyridine core can be further functionalized through different chemical reactions, such as cyanation, to produce a wide range of compounds with diverse applications.
For example, 6'-Methoxy-2,3'-bipyridine can undergo cyanation through rhodium catalysis, which introduces a cyano group (CN) to the molecule. This reaction can be used to synthesize new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 381725-49-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,1,7,2 and 5 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 381725-49:
(8*3)+(7*8)+(6*1)+(5*7)+(4*2)+(3*5)+(2*4)+(1*9)=161
161 % 10 = 1
So 381725-49-1 is a valid CAS Registry Number.
381725-49-1Relevant articles and documents
Synthesis of Pyridylsulfonium Salts and Their Application in the Formation of Functionalized Bipyridines
Duong, Vincent K.,Horan, Alexandra M.,McGarrigle, Eoghan M.
, p. 8451 - 8457 (2020/11/12)
An S-selective arylation of pyridylsulfides with good functional group tolerance was developed. To demonstrate synthetic utility, the resulting pyridylsulfonium salts were used in a scalable transition-metal-free coupling protocol, yielding functionalized bipyridines with extensive functional group tolerance. This modular methodology permits selective introduction of functional groups from commercially available pyridyl halides, furnishing symmetrical and unsymmetrical 2,2′- A nd 2,3′-bipyridines. Iterative application of the methodology enabled the synthesis of a functionalized terpyridine with three different pyridine components.
Process for the preparation of 2-alkoxy-5-(pyridin-2-yl)pyridine, an intermediate of perampanel
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Paragraph 0063, (2013/05/09)
The present invention relates to a process for synthesising 2-alkoxy-5-(pyridin-2-yl)pyridine which is an intermediate of the synthesis of the active substance Perampenel.
A practical, laboratory-scale synthesis of Perampanel
McElhinny Jr., Charles J.,Carroll,Lewin, Anita H.
experimental part, p. 57 - 62 (2012/04/10)
The orally active, noncompetitive, selective AMPA receptor antagonist Perampanel, 2-[1,6-dihydro-6-oxo-1-phenyl-(2,3-bipyridin)-5-yl]benzonitrile, has been prepared from readily available, relatively inexpensive starting materials. The synthesis was carried out on a laboratory scale with no specialized equipment, and involved only two chromatographic purifications. Georg Thieme Verlag Stuttgart. New York.
