383-62-0Relevant articles and documents
METHOD FOR PRODUCING DIFLUORO-ACETYL-ACETIC ACID ALKYLESTERS
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Page 13, (2008/06/13)
The invention relates to a three-stage method for producing 4, 4-difluoro-acetyl-acetic acid alkylesters. In a first stage, a reaction of 4-chloro-4, 4-difluoro-acetyl-acetic acid alkylesters with trialkyl-phosphites of formula (III) P(OR1)3 is carried out, wherein R1 is C1-C4 alkyl, the R1 groups can be identical or different for producing alkyl-phosphonic acid esters of formula (IV) which react with amine of formula (V) during a second stage, wherein R2 and R3 are hydrogen or C1-C4 alkyl independent of each other, or jointly CH2-CH2-O-CH2-CH2- for forming enamines of formula (VI), wherein R2 and R3 have already mentioned significance, said enamines being hydrolysed in the presence of an acid during a third stage.
Process for the preparation of alkyl halodifluoroacetates
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, (2008/06/13)
For the preparation of alkyl halodifluoroacetates, a 1,1-difluorotetrahaloethane is reacted with an alcohol in the presence of air and/or oxygen and a free-radical initiator, such as for example an azo compound, e.g., azobis(isobutyronitrile).