38877-93-9 Usage
Description
(E)-6-(1,3-Dihydro-4,6-diMethoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-4-hexenoic Acid is a complex organic compound that is the dimethoxy analogue of Mycophenolic Acid (M831500). It is characterized by its unique molecular structure, which includes a dihydro-isobenzofuranyl moiety and a methyl-hexenoic acid group. (E)-6-(1,3-Dihydro-4,6-diMethoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-4-hexenoic Acid has gained attention for its potential applications in various fields, particularly as an immunosuppressant drug.
Uses
Used in Pharmaceutical Industry:
(E)-6-(1,3-Dihydro-4,6-diMethoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-4-hexenoic Acid is used as an immunosuppressant drug for preventing organ rejection in transplantation procedures. It functions as a selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, a key enzyme in the de novo synthesis of purine nucleotides. This inhibition helps to suppress the immune response, reducing the risk of transplant rejection and improving the success rate of organ transplants.
Additionally, due to its structural similarity to Mycophenolic Acid, it may also have potential applications in the treatment of autoimmune diseases and inflammatory conditions, where immunosuppression is required to manage the symptoms and progression of the disease. Further research and clinical trials would be necessary to explore these potential applications and establish the safety and efficacy of (E)-6-(1,3-Dihydro-4,6-diMethoxy-7-Methyl-3-oxo-5-isobenzofuranyl)-4-Methyl-4-hexenoic Acid in these contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 38877-93-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,8,7 and 7 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 38877-93:
(7*3)+(6*8)+(5*8)+(4*7)+(3*7)+(2*9)+(1*3)=179
179 % 10 = 9
So 38877-93-9 is a valid CAS Registry Number.
38877-93-9Relevant articles and documents
Mycophenolic acid as a latent agonist of PPARγ
Ubukata, Makoto,Takamori, Hitomi,Ohashi, Misaki,Mitsuhashi, Shinya,Yamashita, Kaoru,Asada, Tomohisa,Nakajima, Noriyuki,Matsuura, Nobuyasu,Tsuruga, Mie,Taki, Keiko,Magae, Junji
, p. 4767 - 4770 (2008/02/11)
Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we u
Total synthesis of mycophenolic acid
Covarrubias-Zú?iga, Adrián,Gonzalez-Lucas, Armando,Domínguez, Mireya M.
, p. 1989 - 1994 (2007/10/03)
A convergent total synthesis of the natural compound mycophenolic acid 1 is described. The synthetic strategy for the construction of the hexasubstituted aromatic nucleus was based on a ring annulation sequence, involving a Michael addition reaction and intramolecular Dieckmann condensation reaction in situ as the key step. Subsequent transformations of the substituents afforded the target mycophenolic acid 1.
