389120-03-0

Basic information

• Product Name: 5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOLE-2-THIOL
• Synonyms: 5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOLE-2-THIOL;1,3,4-Oxadiazole-2(3H)-thione, 5-[4-(trifluoroMethyl)phenyl]-;5-[4-(trifluoromethyl)phenyl]-3H-1,3,4-oxadiazole-2-thione
• CAS NO: 389120-03-0
• Molecular Formula: C₉H₅F₃N₂OS
• Molecular Weight: 246.21
• Mol File: 389120-03-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 252.1 °C at 760 mmHg
• Flash Point: 106.3 °C
• Appearance: /
• Density: 1.54 g/cm³
• Vapor Pressure: 0.0197mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOLE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOLE-2-THIOL(389120-03-0)
• EPA Substance Registry System: 5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOLE-2-THIOL(389120-03-0)

Safety Data

• Hazardous Substances Data: 389120-03-0(Hazardous Substances Data)

Usage

General Description

5-[4-(Trifluoromethyl)phenyl]-1,3,4-oxadiazole-2-thiol is a chemical compound that belongs to the class of oxadiazoles. It is a heterocyclic compound containing a five-membered ring with oxygen, nitrogen, and sulfur atoms. The trifluoromethyl group and phenyl group in its structure make it a valuable building block for the synthesis of various pharmaceuticals and agrochemicals. 5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOLE-2-THIOL has been studied for its potential biological activities, including antimicrobial, antifungal, and antitumor properties. Its unique structural features make it a target for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C9H5F3N2OS/c10-9(11,12)6-3-1-5(2-4-6)7-13-14-8(16)15-7/h1-4H,(H,14,16)

Upstream product

• 75-15-0 carbon disulfide 
• 339-59-3 4-(trifluoromethyl)benzoic acid hydrazide 
• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 583-02-8 ethyl 4-(trifluoromethyl)benzoate 

Downstream Products

• 389120-02-9 2-(6,6,5-trifluorohex-5-enylthio)-5-(4-trifluoromethylphenyl)-1,3,4-oxadiazole 
• 158668-56-5 E-2-Methoxyimino-2-[(2-[5-(4-trifluoromethylphenyl)-1,3,4-oxadiazol-2-yl]thiomethyl)phenyl]-N-methylacetamide 
• 202823-22-1 5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one 
• 1610410-44-0 2-{[6-(4-Fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]thio}-5-[4-(trifluoromethyl)-phenyl]-1,3,4-oxadiazole 
• 1610730-74-9 2-[(8-phenyl-9H-purin-6-yl)thio]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazole 

Relevant articles and documents

Pleuromutilin derivative with 1, 3, 4-oxadiazole side chain and preparation and application thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to a pleuromutilin derivative with a 1, 3, 4-oxadiazole side chain and preparation and application thereof The pleuromutilin derivative with the 1, 3, 4-oxadiazole side chain is a compound shown in a formula 2 or a pharmaceutically acceptable salt thereof, and a solvent compound, an enantiomer, a diastereoisomer and a tautomer of the compound shown in the formula 2 or the pharmaceutically acceptable salt thereof or a mixture of the solvent compound, the enantiomer, the diastereoisomer and the tautomer in any proportion, including a racemic mixture. The pleuromutilin derivative has good antibacterial activity, is especially suitable for being used as a novel antibacterial agent for systemic system infection of animals or human beings, and has good water solubility.

1, 3, 4-oxadiazole-2 (3H)-thioketone-norfloxacin heterozygote and preparation method and application thereof

The invention discloses a 1, 3, 4-oxadiazole-2 (3H)-thioketone-norfloxacin heterozygote and a preparation method and application thereof, and the structural formula of the 1, 3, 4-oxadiazole-2 (3H)-thioketone-norfloxacin heterozygote is shown as a formula

Synthesis and bioactivity of sulfide derivatives containing 1,3,4-oxadiazole and pyridine

A series of novel sulfide derivatives containing 1,3,4-oxadiazole and pyridine were synthesized, characterized, and tested for their antibacterial activity against tobacco bacterial wilt and rice bacterial blight and for insecticidal activity toward diamondback moth. The results showed that some compounds had good insecticidal and bactericidal activity, e.g., the activities of compounds 6e and 6g–6j toward tobacco bacterial wilt were much better than those of commercial thiodiazole-copper, and some of the synthesized compounds possessed good insecticidal activity against Plutella xylostella. Compounds 6d, 6h, 6j, 6l, 6p, 6r, and 6p displayed over 93% activity at 500 mg L? 1.