39155-94-7Relevant articles and documents
Nylon-3 polymers that enable selective culture of endothelial cells
Liu, Runhui,Chen, Xinyu,Gellman, Samuel H.,Masters, Kristyn S.
, p. 16296 - 16299 (2013)
Substrates that selectively encourage the growth of specific cell types are valuable for the engineering of complex tissues. Some cell-selective peptides have been identified from extracellular matrix proteins; these peptides have proven useful for biomat
Hairpin folding behavior of mixed α/β-peptides in aqueous solution
Lengyel, George A.,Frank, Rebecca C.,Horne, W. Seth
supporting information; experimental part, p. 4246 - 4249 (2011/06/21)
The invention of new strategies for the design of protein-mimetic oligomers that manifest the folding encoded in natural amino acid sequences is a significant challenge. In contrast to the α-helix, mimicry of protein β-sheets is less understood. We report
Efficient synthesis of (1R,2S) and (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form
Dragovich, Peter S.,Murphy, Douglas E.,Dao, Kimkim,Kim, Sun Hee,Li, Lian-Sheng,Ruebsam, Frank,Sun, Zhongxiang,Tran, Chinh V.,Xiang, Alan X.,Zhou, Yuefen
experimental part, p. 2796 - 2803 (2009/06/28)
A 4-step synthesis of an optically active synthetic intermediate [(1R,2S)-2-(4′-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic acid; compound 12, >99% de] required for the preparation of a promising HCV NS5B polymerase inhibitor is reported. This process utilizes mandelic acid as a resolving agent, which can be recovered in good yield by a simple extraction. An optimized version of the chemistry described avoids the use of chromatographic purifications making it suitable for large-scale applications. In addition, the straightforward conversion of compound 12 to enantiomerically pure (1R,2S)-2-aminocyclopentanecarboxylic acid ethyl ester and the corresponding Boc and Cbz derivatives is reported. The preparation of the enantiomer of 12 (compound 15) in enantiomerically pure form and the conversion of this entity to (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester and the corresponding Boc and Cbz derivatives is also described.