39160-70-8

Basic information

• Product Name: H2N-PEG6-OH
• Synonyms: H2N-PEG6-OH;1-AMinohexaethylene Glycol;17-AMino-3,6,9,12,15-pentaoxaheptadecanol;H2N-PEG6-OH;Amino-PEG6-alcohol;3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-amino-;NH2-PEG6-OH
• CAS NO: 39160-70-8
• Molecular Formula: C₁₂H₂₇NO₆
• Molecular Weight: 281.34588
• EINECS: 227-918-6
• Product Categories: Aliphatics;Amines;Intermediates;Polyethyleneglycol Derivatives
• Mol File: 39160-70-8.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 388.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.083±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Soluble in Water, DMSO, DCM, DMF
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: H2N-PEG6-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H2N-PEG6-OH(39160-70-8)
• EPA Substance Registry System: H2N-PEG6-OH(39160-70-8)

Safety Data

• Hazardous Substances Data: 39160-70-8(Hazardous Substances Data)

Usage

Description

H2N-PEG6-OH, also known as Amino-PEG6-alcohol, is a polyethylene glycol (PEG) derivative featuring one amino group (NH2) and a hydroxyl group. This PEG reagent is characterized by its hydrophilic PEG spacer, which enhances solubility in aqueous media, and a reactive amine group that can interact with carboxylic acids and activated NHS esters.

Uses

Used in Pharmaceutical Industry:
H2N-PEG6-OH is used as a PEGylation agent for improving the solubility, stability, and bioavailability of therapeutic proteins and drugs. The hydrophilic PEG spacer reduces the immunogenicity and proteolytic degradation of the conjugated molecules, thus extending their circulation time in the body.
Used in Diagnostics:
H2N-PEG6-OH is used as a key component in the preparation of single-cell optical biosensors. The hydrophilic PEG spacer and reactive amine group facilitate the attachment of specific recognition elements, such as antibodies or other binding molecules, to the sensor surface, enabling the detection and analysis of target analytes at the single-cell level.
Used in Drug Delivery Systems:
H2N-PEG6-OH is used as a building block for the development of novel drug delivery systems, such as nanoparticles and micelles. The PEG spacer improves the solubility and biocompatibility of these systems, while the reactive amine group allows for the conjugation of therapeutic agents, targeting moieties, or imaging agents to enhance their specificity and efficacy.
Used in Bioconjugation and Chemical Synthesis:
H2N-PEG6-OH is used as an intermediate in the synthesis of various bioconjugates, such as PEGylated proteins, peptides, and small molecules. The reactive amine group can be used to form stable amide or urea linkages with carboxylic acid-containing compounds, enabling the creation of diverse PEGylated products with tailored properties and applications.

Upstream product

• 141282-27-1 2-(17-hydroxy-3,6,9,12,15-pentaoxaheptadecyl)isoindoline-1,3-dione 
• 2615-15-8 pentaethylene glycol 
• 1663-39-4 tert-Butyl acrylate 
• 1444123-36-7 C₃₁H₃₉N₃O₆ 
• 745048-16-2 19,19,19-triphenyl-3,6,9,12,15,18-hexaoxanonadec-1-ylmethanesulfonate 
• 127999-16-0 19-(triphenylmethyl)-1,4,7,10,13,16,19-heptaoxanonadecanol 
• 24342-68-5 1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol 
• 669556-37-0 17-(tetrahydro-2H-pyran-2-yloxy)-3,6,9,12,15-pentaoxaheptadecyl 4-methylbenzenesulfonate 
• 112-60-7 Tetraethylene glycol 
• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 
• 42749-28-0 toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester 
• 352439-34-0 17-hydroxy-3,6,9,12,15-pentaoxaheptadec-1-yl methanesulfonate 
• 86770-73-2 {2-[2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxymethyl}-benzene 
• 86770-69-6 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol 

Downstream Products

• 250330-58-6 benzyl N-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate 
• 250330-71-3 N-benzyloxycarbonyl-1-amino-1-deoxyhexaethylene glycol 4-O-cellobioside 
• 250330-70-2 N-benzyloxycarbonyl-1-amino-1-deoxyhexaethylene glycol 4-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2,3,6-tri-O-acetyl-β-D-glucopyranoside 
• 250330-65-5 N-benzyloxycarbonyl-1-amino-1-deoxyhexaethylene glycol 4-O-(4-O-(α-D-glucopyranosyl)-α-D-glucopyranosyl)-β-D-glucopyranoside 
• 250330-64-4 N-benzyloxycarbonyl-1-amino-1-deoxyhexaethylene glycol 4-O-(4-O-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-2,3,6-tri-O-acetyl-α-D-glucopyranosyl)-2,3,6-tri-O-acetyl-β-D-glucopyranoside 
• 1219133-47-7 C₄₈H₈₉NO₁₀ 
• 1219133-43-3 C₆₁H₁₁₅NO₁₀ 
• 1264015-86-2 3'-(4{2-[2-(2-{2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}-3,5-bis[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]benzoylamino)-2,2'-bipyridine-3-amine 
• 1264015-76-0 2-{2-[2-(2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy)ethoxy]ethoxy}ethyl p-tosylate 
• 1264015-79-3 methyl 4-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}-3,5-bis[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]benzoate 
• 1264015-81-7 4-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}-3,5-bis[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]benzoic acid 
• 1264015-83-9 C₄₆H₈₂ClNO₂₁ 
• 1584544-42-2 1-{2-[2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}pyrrole-2,5-dione 
• 911209-07-9 tert-butyl N-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate 

Relevant articles and documents

Development of chemically stable solid phases for the target isolation with reduced nonspecific binding proteins

Poly(methacrylate) matrices for affinity resins were designed and synthesized based on our previous results that nonspecific protein absorption on affinity resins strongly depended on their hydrophobic property. The novel affinity resins bearing FK506 (6a, 6b) captured specific binding protein, FKBP12, with a small amount of nonspecific binding proteins. The amount of nonspecific binding proteins on 6a-6b was much reduced compared to that on commercially available poly(methacrylate) resins, Toyopearl (8), and was almost the same as that on one of the most popular resins, Affigel (9). Interestingly, 6a and 6b could isolate FKBP52 as a specific binding protein as well, although 8 and 9 could not.

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A compound was synthesized that binds to a phospholipid bilayer via a hydrophobic steroid thereby projecting a strong multi-hydrogen bonding unit into the surrounding water. As shown by light scattering, light microscopy, and cryo-HRSEM, this latter unit self-adheres and induces membrane-membrane attachments, as found in many biological systems. Copyright

THERAPEUTIC CURE-PRO COMPOUNDS FOR TARGETED DEGRADATION OF BET DOMAIN PROTEINS, AND METHODS OF MAKING AND USING THEM

The present application is directed to a therapeutically useful compound, comprised of two monomers that are linked to each other through two or more reversible covalent bonds. Each monomer is a polyfunctionalized molecule comprising a bioorthogonal linker element and ligand or pharmacophore, wherein the linker and ligand/pharmacophore are covalently coupled to each other either directly or through an optional connector moiety.

PROTAC compound for targeted degradation of IDO1, and preparation method and application thereof

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