39255-20-4

Basic information

• Product Name: 1-(4'-Bromophenoxy)-1-ethoxyethane
• Synonyms: 1-(4'-BROMOPHENOXY)-1-ETHOXYETHANE;1-BROMO-4-(2-ETHOXYETHOXY)-BENZENE;1-(4'-Bromophenoxy)-1-ethoxyethane, tech., 90%;Benzene, 1-bromo-4-(1-ethoxyethoxy)-;1-(4'-Bromophenoxy)-1-ethoxyethane,90%, tech;1-(4-BroMophenoxy)-1-ethoxyenethane
• CAS NO: 39255-20-4
• Molecular Formula: C₁₀H₁₃BrO₂
• Molecular Weight: 245.11
• EINECS: 254-383-6
• Mol File: 39255-20-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 130-132 °C
• Flash Point: 106.1°C
• Appearance: white powder
• Density: 1.4154 (rough estimate)
• Refractive Index: 1.521-1.523
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(4'-Bromophenoxy)-1-ethoxyethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4'-Bromophenoxy)-1-ethoxyethane(39255-20-4)
• EPA Substance Registry System: 1-(4'-Bromophenoxy)-1-ethoxyethane(39255-20-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37
• Safety Statements: 24/25
• Hazardous Substances Data: 39255-20-4(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR GREEN-YELLOW LIQUID

Upstream product

• 106-41-2 4-bromo-phenol 
• 628-34-2 2-chloroethyl ethyl ether 
• 592-55-2 2-Bromoethyl ethyl ether 
• 83391-63-3 2-chloroethyl-ethyl ether 

Downstream Products

• 362476-94-6 (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester 
• 362477-50-7 C₁₂H₁₈ClO₄P 
• 362477-41-6 diethyl 4-(2-ethoxyethoxy)phenylphosphonate 
• 279262-15-6 {4-[2-(ethoxy)ethoxy]phenyl}boronic acid 

Relevant articles and documents

Orally active CCR5 antagonists as anti-HIV-1 agents: Synthesis and biological activity of 1-benzothiepine 1,1-dioxide and 1-benzazepine derivatives containing a tertiary amine moiety

The search for orally active CCR5 antagonists was performed by chemical modification of the 1-benzothiepine 1,1-dioxide 3 and 1-benzazepine 4 lead compounds containing a tertiary amine moiety. Replacement of methyl group with a 2-(C2-4 alkoxy)ethoxy group at the 4-position on the 7-phenyl group of the 1-benzothiepine ring resulted in both enhanced activity and significant improvement in the pharmacokinetic properties upon oral administration in rats. Introduction of C2-4 alkyl, phenyl or (hetero)arylmethyl groups as the 1-substituent on the 1-benzazepine ring together with the 2-(butoxy)ethoxy group led to further increase of activity. Among the 1- benzazepine derivatives, the isobutyl (6i), benzyl (6o) or 1-methylpyrazol-4-ylmethyl (6s) compounds were found to exhibit highly potent inhibitory effects, equivalent to the injectable CCR5 antagonist 1, in the HIV-1 envelopemediated membrane fusion assay. In particular, compound 6s showed the most potent CCR5 antagonistic activity (IC50=2.7 nM) and inhibitory effect (IC50=1.2 nM) on membrane fusion, together with good pharmacokinetic properties in rats. The synthesis of 1-benzothiepine 1,1-dioxide and 1-benzazepine derivatives and their biological activity are described.

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n is an integer of 1 or 2; Z is a chemical bond or a divalent group; R2is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of the formula: ?wherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R5and R6are independently an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted amino group, and R5and R6may bind to each other to form a cyclic group together with the adjacent phosphorus atom, or a salt thereof , which is useful for antagonizing CCR5 and also for the prevention and treatment of infectious disease of HIV.