392686-83-8Relevant articles and documents
A synthetic approach to the plakoridines modeled on a biogenetic theory
Etchells, Laura L.,Sardarian, Ali,Whitehead, Roger C.
, p. 2803 - 2807 (2005)
An expedient synthetic route to the fully substituted pyrrolidine ring system of the plakoridines is described using an approach modeled on a plausible biosynthetic pathway.
Facile synthesis and in vitro properties of 1-alkyl- and 1-alkyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline derivatives on PC12 cells
Kitabatake, Michikazu,Nagai, Junko,Abe, Kenji,Tsuchiya, Yukihiro,Ogawa, Keita,Yokoyama, Takashi,Mohri, Kunihiko,Taguchi, Kyoji,Horiguchi, Yoshie
experimental part, p. 4034 - 4043 (2009/12/04)
The synthesis of several 1-alkyl-1,2,3,4-tetrahydroisoquinolines, which may play an important role in Parkinson's disease, has been achieved by modified Pictet-Spengler cyclization of the formyliminium ion. The direct cytotoxicity and preventative effects
Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase
Doncaster, Jeremy R.,Etchells, Laura L.,Kershaw, Neil M.,Nakamura, Ryoichi,Ryan, Hazel,Takeuchi, Ryo,Sakaguchi, Kengo,Sardarian, Ali,Whitehead, Roger C.
, p. 2877 - 2881 (2007/10/03)
An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases α and β and human terminal deoxynucleotidyl transferase (TdT).
