894086-16-9Relevant articles and documents
Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase
Doncaster, Jeremy R.,Etchells, Laura L.,Kershaw, Neil M.,Nakamura, Ryoichi,Ryan, Hazel,Takeuchi, Ryo,Sakaguchi, Kengo,Sardarian, Ali,Whitehead, Roger C.
, p. 2877 - 2881 (2006)
An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases α and β and human terminal deoxynucleotidyl transferase (TdT).
