3938-83-8

Basic information

• Product Name: (S)-4-amino-2-hydroxybutanoic acid
• CAS NO: 3938-83-8
• Molecular Weight: 119.12
• Mol File: 3938-83-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-4-amino-2-hydroxybutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-amino-2-hydroxybutanoic acid(3938-83-8)
• EPA Substance Registry System: (S)-4-amino-2-hydroxybutanoic acid(3938-83-8)

Safety Data

• Hazardous Substances Data: 3938-83-8(Hazardous Substances Data)

Usage

Description

(S)-4-amino-2-hydroxybutanoic acid, also known as L-threonine, is a non-essential amino acid that is vital for the biosynthesis of proteins. It is one of the 20 standard amino acids found in proteins and is crucial for maintaining proper growth, immune function, and the formation of collagen and elastin in the body. L-threonine also serves as a precursor for the synthesis of glycine, an inhibitory neurotransmitter in the central nervous system.

Uses

Used in Pharmaceutical Applications:
L-threonine is used as a pharmaceutical ingredient for promoting proper growth and immune function. It is essential for the body's ability to produce collagen and elastin, which are vital for healthy skin, hair, and nails.
Used in Nutritional Supplements:
L-threonine is used as a nutritional supplement to support overall health and well-being. It can be found in various dietary sources, including eggs, dairy products, certain meats, leafy green vegetables, nuts, and seeds, making it an important component of a balanced and healthy diet.
Used in the Central Nervous System:
L-threonine is used as a precursor for the synthesis of glycine, an inhibitory neurotransmitter in the central nervous system. This application helps maintain proper neurological function and supports the overall health of the brain and nervous system.
Used in the Food Industry:
L-threonine is used in the food industry as a natural additive to enhance the nutritional value of various products. It can be added to dietary supplements, protein powders, and other health products to support the body's amino acid requirements and promote overall health.
Used in Cosmetics:
L-threonine is used in the cosmetics industry for its role in promoting healthy skin, hair, and nails. It can be found in various skincare and hair care products, contributing to their nourishing and protective properties.
Used in Research and Development:
L-threonine is used in research and development for its potential applications in various fields, including pharmaceuticals, nutrition, and cosmetics. Its role in protein synthesis, immune function, and neurotransmitter production makes it a valuable compound for scientific study and innovation.

Upstream product

• 1758-80-1 L-2,4-diaminobutyrate 
• 56-12-2 4-amino-n-butyric acid 
• 40371-50-4 S-4-benzyloxycarbonylamino-2-hydroxybutyric acid 
• 40732-91-0 γ-phthalimidoimino-α-hydroxybutyric acid 
• 57229-74-0 (S)-2-hydroxysuccinamic acid 

Downstream Products

• 111607-75-1 (S)-hydroxy-3 phenylacetyl-1 pyrrolidinone-2 
• 850397-64-7 4-Benzyloxycarbonylamino-2S-hydroxy butyric acid ethyl ester 
• 48172-10-7 (+)-(2S)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybutanoic acid 
• 1455088-71-7 (S)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-2-hydroxybutanoic acid 
• 1455086-97-1 2-(S)-hydroxy-4-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid 
• 1221492-53-0 N,N'-bis(benzyloxycarbonyl)-2-(S)-hydroxy-4-guanidino-butyric acid 
• 149137-92-8 (2S)-4-(p-nitrobenzyloxycarbonyl)-amino-2-hydroxybutyric acid 
• 207305-60-0 (S)-4-[(tert-butoxycarbonyl)amino]-2-hydroxybutanoic acid 
• 188753-46-0 (S)-2-Hydroxy-4-(5-methyl-2-nitro-phenylamino)-butyric acid 
• 40371-50-4 S-4-benzyloxycarbonylamino-2-hydroxybutyric acid 
• 34368-52-0 (S)-3-hydroxypyrrolidin-2-one 

Relevant articles and documents

α-Hydroxylation of Carboxylic Acids Catalyzed by Taurine Dioxygenase

Enzymes still have a limited application scope in synthetic organic chemistry. To expand this, different strategies exist that range from the de novo design of enzymes to the exploitation of the catalytic capabilities of known enzymes by converting different substrates; denoted as substrate promiscuity. We harnessed the synthetic potential offered by the taurine dioxygenase (TauD) from Escherichia coli (E. coli) by studying its promiscuous catalytic properties in the hydroxylation of carboxylic acid substrates. TauD showed high selectivities in the hydroxylation reaction but reduced levels of activity (26 % conversion, >96 % ee). We enhanced the enzyme substrate scope and improved the conversions for the tested substrates by introducing a point mutation at position 206 (F206Y). The conversions of the improved catalyst increased by at least 140 % compared to that of the wild-type enzyme. The number of carboxylic acids that accepted by the enzyme variant doubled from four to eight carboxylic acids.

Hydroxylations microbiologiques de pyrrolidinones-2 (note de laboratoire)

Microbial hydroxylations of various pyrrolidin-2 ones, especially N-acylated, with Beauveria sulfurescens have been carried out.The regioselectivity depends on the nature of the substituent on the nitrogen atom and the hydroxylation may occur at position 3,4 or 5 of the heterocycle.Hydroxylations at position 3 or 4 occur with low enantioselectivity.

Aminoglycoside antibiotics. II. Configurational and positional isomers of BB-K8

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