39489-79-7 Usage
Description
2,4-Dichloro-5-hydroxyaniline, also known as 5-Amino-2,4-dichlorophenol, is an organic compound that exists as an off-white to beige crystalline powder. It is characterized by the presence of a hydroxyl group and two chlorine atoms attached to the benzene ring, which contribute to its chemical properties and potential applications.
Uses
Used in Chemical Synthesis:
2,4-Dichloro-5-hydroxyaniline is used as an intermediate in the chemical synthesis industry for the preparation of aromatic amines and chloroacetyl derivatives. Its unique structure allows it to serve as a building block for the creation of various compounds with different applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4-Dichloro-5-hydroxyaniline may be used as a starting material for the synthesis of drugs with potential therapeutic applications. Its chemical properties make it a versatile compound for the development of new medications.
Used in Dye and Pigment Industry:
2,4-Dichloro-5-hydroxyaniline's chemical structure also makes it suitable for use in the dye and pigment industry, where it can be utilized in the production of various colorants for different applications, such as textiles, plastics, and printing inks.
Used in Agrochemical Industry:
2,4-Dichloro-5-hydroxyaniline may also find applications in the agrochemical industry, where it could be used as a precursor for the synthesis of pesticides or other agricultural chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 39489-79-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,4,8 and 9 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 39489-79:
(7*3)+(6*9)+(5*4)+(4*8)+(3*9)+(2*7)+(1*9)=177
177 % 10 = 7
So 39489-79-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H5Cl2NO/c7-3-1-4(8)6(10)2-5(3)9/h1-2,10H,9H2
39489-79-7Relevant articles and documents
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Letsinger,Wubbels
, p. 5041 (1966)
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Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity
Boschelli,Ye,Wang,Dutia,Johnson,Wu,Miller,Powell,Yaczko,Young,Tischler,Arndt,Discafani,Etienne,Gibbons,Grod,Lucas,Weber,Boschelli
, p. 3965 - 3977 (2007/10/03)
Subsequent to the discovery of 4-[(2,4-dichlorophenyl)amino] -6,7-dimethoxy-3-quinolinecarbonitrile (1a) as an inhibitor of Src kinase activity (IC50 = 30 nM) several additional analogues were prepared. Optimization of the C-4 anilino group of la led to lc which contains a 2,4-dichloro-5-methoxy- substituted aniline. Replacement of the methoxy group at C-7 of 1c with a 3-(morpholin-4-yl)propoxy group provided 2c resulting in increased inhibition of both Src kinase activity and Src-mediated cell proliferation. Analogues of 2c with other trisubstituted anilines at C-4 were also potent Src inhibitors and the propoxy group of 2c was preferred over ethoxy butoxy or pentoxy. Replacement of the morpholine group of 2c with a 4-methylpiperazine group provided 31a which had an IC50 of 1.2 nM in the Src enzymatic assay an IC50 of 100 nM for the inhibition of Src-dependent cell proliferation and was selective for Src over non-Src family kinases. Compound 31a which had higher 1 and 4 h plasma levels than 2c effectively inhibited tumor growth in xenograft models.
