39489-77-5 Usage
Description
2,4-Dichloro-5-nitrophenol is an organic compound characterized by the presence of two chlorine atoms at the 2nd and 4th positions, and a nitro group at the 5th position on a phenol molecule. It serves as a versatile intermediate in the synthesis of various biologically active compounds.
Uses
Used in Pharmaceutical Industry:
2,4-Dichloro-5-nitrophenol is used as a chemical intermediate for the preparation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines, which are potent Dipeptidyl Peptidase IV (DPP-IV) inhibitors. These inhibitors play a crucial role in managing type 2 diabetes by regulating glucose levels in the body.
Additionally, 2,4-Dichloro-5-nitrophenol is utilized in the synthesis of cyanopyrrolo[2,3-d]pyrimidine derivatives, which act as Hsp90 (Heat shock protein 90) inhibitors. Hsp90 inhibitors are valuable in the development of anticancer drugs, as they target a protein that is essential for the stability and function of multiple client proteins involved in cancer cell survival and proliferation.
Check Digit Verification of cas no
The CAS Registry Mumber 39489-77-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,4,8 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 39489-77:
(7*3)+(6*9)+(5*4)+(4*8)+(3*9)+(2*7)+(1*7)=175
175 % 10 = 5
So 39489-77-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H3Cl2NO3/c7-3-1-4(8)6(10)2-5(3)9(11)12/h1-2,10H
39489-77-5Relevant articles and documents
Synthesis process of oxadiazon intermediate 2, 4-dichloro-5-nitrophenol
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Paragraph 0010; 0029-0034, (2021/05/08)
The invention discloses a synthesis process of oxadiazon intermediate nitrophenol, and the synthesis process comprises the following steps: adding metered dichlorophenol into a sulfonation nitration kettle, then dropwise adding concentrated sulfuric acid, after the reaction is completed, performing cooling, adding a solvent for dissolving, then directly dropwise adding mixed acid for nitration, and then performing hydrolyzing to obtain the intermediate 2, 4-dichloro-5-nitrophenol. Compared with a conventional nitrophenol synthesis method, the method has the advantages that the operation process is simple, the process route is simplified, sulfonation and nitration steps can be carried out in the same kettle, production equipment is reduced, discharge of phosphorus-containing wastewater is avoided, and the method has high industrial production value.
Hair dye coupler and process for making
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, (2008/06/13)
A substituted m-aminophenol coupler useful in hair dyeing having the formula STR1 and acid addition salts thereof wherein x and y are selected from the group consisting of halogen and the groups OR of which R is the same or different alkyl, aminoalkyl or hydroxyalkyl groups, at least one of x or y being a group OR and a process for preparing these compounds.
