395-00-6

Basic information

• Product Name: ALPHA,BETA-DIFLUORO-BETA-CHLOROSTYRENE
• Synonyms: ALPHA,BETA-DIFLUORO-BETA-CHLOROSTYRENE;alpha,Difluoro-chlorostyrene;ALPHA,SS-DIFLUORO-SS-CHLOROSTYRENE
• CAS NO: 395-00-6
• Molecular Formula: C₈H₅ClF₂
• Molecular Weight: 174.58
• Mol File: 395-00-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 72-73°C 20mm
• Appearance: /
• CAS DataBase Reference: ALPHA,BETA-DIFLUORO-BETA-CHLOROSTYRENE(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA,BETA-DIFLUORO-BETA-CHLOROSTYRENE(395-00-6)
• EPA Substance Registry System: ALPHA,BETA-DIFLUORO-BETA-CHLOROSTYRENE(395-00-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 395-00-6(Hazardous Substances Data)

Usage

Chemical Classification

Organic compound, Halogenated hydrocarbon

Composition

Contains both fluorine and chlorine atoms

Common Uses

Production of various polymers and resins
Synthesis of pharmaceuticals and agrochemicals

Other Applications

Organic synthesis
Building block for the development of new materials and compounds

Safety Concerns

Requires careful handling due to potential health and environmental risks if not properly managed

Upstream product

• 14006-62-3 (Z)-2-chloro-1,2-difluoro-1-iodo-ethene 
• 98-80-6 phenylboronic acid 
• 3220-49-3 phenyl copper 
• 62269-26-5 α,β-difluoro-β-chlorovinyllithium 
• 79-38-9 Chlorotrifluoroethylene 
• 591-51-5 phenyllithium 

Downstream Products

• 720-42-3 Z-1-fluoro-2-chloro-1,2-diphenylethylene 
• 20488-54-4 trans-1,2-difluoro-1,2-diphenylethylene 
• 1129-65-3 (hex-1-yn-1-yl)benzene 
• 56424-18-1 1-Fluor-1-phenyl-essigsaeurebutylester 
• 56424-19-2 2-Butoxy-2-chlor-1-fluor-1-phenyl-ethylen 
• 41073-08-9 α-Fluorphenylessigsaeure-diethylamid 
• 56424-22-7 2-Butylthio-2-chlor-1-fluor-1-phenyl-ethylen 
• 56424-23-8 α-phenyl-α,β,β,β-tetrafluoroethane 
• 113894-39-6 trans-α,β-difluorocinnamaldehyde 
• 126912-49-0 (E)-2,3-Difluoro-3-phenyl-1-(4-trifluoromethyl-phenyl)-prop-2-en-1-ol 
• 111483-27-3 β-trimethylsilyl-α,β-difluorostyrene 
• 129403-30-1 4'-trifluoromethyl-α,β-difluorochalcone 
• 52158-22-2 trans-α,β-difluorocinnamic acid 
• 126912-47-8 (E)-1-(4-Dimethylamino-phenyl)-2,3-difluoro-3-phenyl-prop-2-en-1-ol 

Relevant articles and documents

Stereospecific synthesis of unsymmetrical (E)- and (Z)-1,2-difluorostilbenes

The synthesis of 1,2-difluorostilbenes via a Susuki reaction using a benzene/ethanol/water solvent mixture required long reaction times and generated significant quantities of a homo-coupled boronic acid product, which was difficult to separate. Therefore, we attempted 1,4-dioxane as a solvent for these reactions, which showed remarkable increased reaction rates and minimized the amount of homo-coupled products to aid in purification. Both (E)- and (Z)-1-chloro-1,2-difluorostyrenes stereospecifically gave the 1,2-difluorostilbenes in moderate to excellent yields. We investigated 4 protocols for the reaction. Protocols 2 and 3 were recommended for scale up, since the chlorostyrene starting material can be obtained in large quantities stereospecifically as described in previous reports. This work represents the first practical synthesis of unsymmetrical (E)- and (Z)-1,2-difluorostilbenes from readily available starting materials.