39538-68-6

Basic information

• Product Name: 2-methoxy-p-toluidine
• Synonyms: 2-methoxy-p-toluidine;2-Methoxy-4-methylaniline 98%
• CAS NO: 39538-68-6
• Molecular Formula: C8H11NO
• Molecular Weight: 137.17904
• EINECS: 254-498-1
• Product Categories: Amines;Building Blocks;C8;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 39538-68-6.mol
• Article Data: 24

Chemical Properties

• Melting Point: 31-33℃
• Boiling Point: 236.9°Cat760mmHg
• Flash Point: 104°C
• Appearance: /
• Density: 1.043g/mLat 25℃
• Vapor Pressure: 0.0462mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.97±0.10(Predicted)
• CAS DataBase Reference: 2-methoxy-p-toluidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-p-toluidine(39538-68-6)
• EPA Substance Registry System: 2-methoxy-p-toluidine(39538-68-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 39538-68-6(Hazardous Substances Data)

Usage

General Description

2-Methoxy-p-toluidine is a chemical compound with the formula C8H11NO. It is an aromatic amine and a derivative of toluidine, which is commonly used as a precursor for the production of dyes and pigments. 2-methoxy-p-toluidine is also utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-methoxy-p-toluidine has been studied for its potential use in the treatment of cancer, as well as its role in the development of tumors. Additionally, it has been identified as a potential occupational hazard due to its toxic and irritating properties. Overall, 2-methoxy-p-toluidine is a versatile chemical with various industrial and biomedical applications, but its potential health risks should be carefully considered in its handling and use.

InChI:InChI=1/C8H11NO/c1-6-3-4-7(9)8(5-6)10-2/h3-5H,9H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 132540-70-6 C₁₂H₁₇NO₂ 
• 121-69-7 N,N-dimethyl-aniline 
• 38512-82-2 3-methoxy-4-nitrotoluene 
• 23438-17-7 4-methoxy-4-methylcyclohexa-2,5-dien-1-one 
• 106-44-5 p-cresol 
• 89978-56-3 1-bromo-4-methoxy-2-methyl-5-nitro-benzene 
• 108-39-4 3-methyl-phenol 
• 700-38-9 2-nitro-5-methylphenol 
• 7647-01-0 hydrogenchloride 
• 50-00-0 formaldehyd 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 186583-59-5 1-iodo-2-methoxy-4-methylbenzene 
• 95740-49-1 1-bromo-2-methoxy-4-methylbenzene 
• 143359-98-2 acetic acid-(2-methoxy-3-methyl-anilide) 
• 76663-23-5 2-(2-Methoxy-4-methyl-phenylamino)-N-(4-sulfamoyl-phenyl)-acetamide 
• 88502-22-1 1-(2-Methoxy-4-methyl-phenyl)-2-methyl-5-(4-nitro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 808114-08-1 (2-methoxy-4-methylphenyl)phenylamine 
• 4532-33-6 1-methoxy-3-methylcarbazole 
• 80389-40-8 3-methoxy-5-methyl anthranilic acid 
• 7320-52-7 3-methyldibenzo[b,d]furan 
• 59517-25-8 2,2'-Bis-benzoyloxy-4,4'-dimethyl-biphenyl 
• 1175699-81-6 9-(3,5-dimethoxyphenyl)-5-methoxy-7-methyl-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one 
• 1356492-48-2 (4,6-dichloro-[1,3,5]triazin-2-yl)-(2-methoxy-4-methyl-phenyl)-amine 
• 1356492-51-7 6-chloro-N-(2-methoxy-4-methyl-phenyl)-N'-pentyl-[1,3,5]triazine-2,4-diamine 
• 1356492-52-8 6-chloro-N-isopropyl-N'-(2-methoxy-4-methyl-phenyl)-[1,3,5]triazine-2,4-diamine 

Relevant articles and documents

CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum

Fluorescent bioorthogonal smart probes across the visible spectrum will enable sensitive visualization of metabolically labeled molecules in biological systems. Here we present a unified design, based on the principle of photoinduced electron transfer, to access a panel of highly fluorogenic azide probes that are activated by conversion to the corresponding triazoles via click chemistry. Termed the CalFluors, these probes possess emission maxima that range from green to far red wavelengths, and enable sensitive biomolecule detection under no-wash conditions. We used the CalFluor probes to image various alkyne-labeled biomolecules (glycans, DNA, RNA, and proteins) in cells, developing zebrafish, and mouse brain tissue slices.

Discovery of Rogaratinib (BAY 1163877): a pan-FGFR Inhibitor

Rogaratinib (BAY 1163877) is a highly potent and selective small-molecule pan-fibroblast growth factor receptor (FGFR) inhibitor (FGFR1–4) for oral application currently being investigated in phase 1 clinical trials for the treatment of cancer. In this publication, we report its discovery by de novo structure-based design and medicinal chemistry optimization together with its pharmacokinetic profile.

Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers

We report the synthesis of a series of distance-matching aryl and vinylaryl cross-linkers for constructing stapled peptides containing cysteines at i,i+7 positions. Langevin dynamics simulation studies helped to classify these cross-linkers into two categories: the rigid cross-linkers with narrower S-S distance distribution and the flexible cross-linkers with wider S-S distance distribution. The stapled Noxa BH3 peptides with the flexible distance-matching cross-linkers gave the highest degree of helicity as well as the most potent inhibitory activity against Mcl-1. However, the stapled peptides with the highest hydrophobicity showed the most efficient cellular uptake. Together, this work illustrates the divergent nature of binding affinity and cellular uptake, and the vital importance of choosing appropriate cross-linkers in constructing stapled peptides with the drug-like properties.