808114-08-1

Basic information

• Product Name: Benzenamine, 2-methoxy-4-methyl-N-phenyl- (9CI)
• Synonyms: Benzenamine, 2-methoxy-4-methyl-N-phenyl- (9CI)
• CAS NO: 808114-08-1
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.275
• Product Categories: METHYL
• Mol File: 808114-08-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenamine, 2-methoxy-4-methyl-N-phenyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2-methoxy-4-methyl-N-phenyl- (9CI)(808114-08-1)
• EPA Substance Registry System: Benzenamine, 2-methoxy-4-methyl-N-phenyl- (9CI)(808114-08-1)

Safety Data

• Hazardous Substances Data: 808114-08-1(Hazardous Substances Data)

Upstream product

• 808114-07-0 6-methyl-3-phenyl-2,3-dihydrobenzoxazol-2-one 
• 591-50-4 iodobenzene 
• 39538-68-6 2-methoxy-4-methylaniline 
• 1421367-18-1 6-diazo-3-methyl-2-cyclohexen-1-one 
• 808113-99-7 2,3,4,5,6,7-hexahydro-2-oxo-3-phenylbenzo[d]oxazole-6-carbaldehyde 
• 153897-88-2 4,5-dimethylene-3-phenyl-1,3-oxazolidin-2-one 
• 38512-82-2 3-methoxy-4-nitrotoluene 
• 700-38-9 2-nitro-5-methylphenol 
• 278172-09-1 5-methyl-2-(phenylamino)phenol 
• 74-88-4 methyl iodide 
• 62-53-3 aniline 

Downstream Products

• 4532-33-6 1-methoxy-3-methylcarbazole 
• 723-97-7 murrayanine 

Relevant articles and documents

"on Water" Promoted Ullmann-Type C-N Bond-Forming Reactions: Application to Carbazole Alkaloids by Selective N-Arylation of Aminophenols

The Ullmann-type cross coupling of a variety of aromatic, aliphatic amines with aryl halides is reported using a CuI-based catalytic system in combination with an easily accessible prolinamide ligand in aqueous media. The method is mild and tolerant to air, moisture, and a wide range of functional groups, providing a novel way to access a variety of aminated products. Secondary amines like heteroaromatic amines and nucleobases have also been used, affording the corresponding coupling products in good to excellent yields. Moreover, this method has been employed for chemoselective C-N arylation of aminophenols and further utilized for the synthesis of carbazole natural products, avoiding the protection and deprotection steps.

Copper-catalyzed N=H insertion and oxidative aromatization cascade: Facile synthesis of 2-arylaminophenols

A copper-catalyzed cascade reaction of N-H insertion and oxidative aromatization has been developed. 2-Arylaminophenols have been prepared in moderate to high yields from the diazo substrates. Moreover, this newly established methodology allows efficient access to natural 1-oxygenated carbazole alkaloids, such as glycozolicine and murrayafoline A. Copper falls: A copper-catalyzed cascade reaction of N=H insertion and oxidative aromatization yields 2-arylaminophenols. This newly established methodology also allows efficient access to natural 1-oxygenated carbazole alkaloids, such as glycozolicine and murrayafoline A.

Acid-free synthesis of carbazoles and carbazolequinones by intramolecular Pd-catalyzed, microwave-assisted oxidative biaryl coupling reactions efficient syntheses of murrayafoline A, 2-methoxy-3-methylcarbazole, and glycozolidine

A mild and. efficient methodology for the synthesis of oxygenated. carbazoles from diarylamines under non-acidic conditions was developed, based on a palladium-catalyzed, microwave-assisted double C-H bond activation process. This new protocol was successfully applied to the synthesis of three naturally occurring carbazoles, namely murrayafoline A, 2-methoxy-3-methylcarbazole, and glycozolidine. The scope of the reaction was also expanded, to include the synthesis of benzo fused carbazolequinones. Wiley-VCH Verlag GmbH & Co. KGaA.