39627-61-7

Basic information

• Product Name: 7-METHYL-1-INDANONE
• Synonyms: 7-Methyl-indan-1-one;1-Indanone-7-carboxylic acid;7-methyl-2,3-dihydro-1H-inden-1-one;7-methlyindanone
• CAS NO: 39627-61-7
• Molecular Formula: C₁₀H₁₀O
• Molecular Weight: 146.1858
• Mol File: 39627-61-7.mol
• Article Data: 26

Chemical Properties

• Melting Point: 52-56 °C
• Boiling Point: 260.4 ºCat 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.113
• Vapor Pressure: 0.0123mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-METHYL-1-INDANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYL-1-INDANONE(39627-61-7)
• EPA Substance Registry System: 7-METHYL-1-INDANONE(39627-61-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 39627-61-7(Hazardous Substances Data)

Usage

General Description

7-Methyl-1-Indanone is a chemical compound with the molecular formula C10H10O. It is a colorless to pale yellow liquid with a sweet, floral odor. 7-Methyl-1-Indanone is commonly used as a fragrance ingredient in perfumes and other scented products. It is also used in the synthesis of pharmaceuticals and other organic compounds. The compound may be harmful if swallowed, and exposure to the skin or eyes can cause irritation. Overall, 7-Methyl-1-Indanone is a versatile chemical with multiple industrial applications.

InChI:InChI=1/C10H10O/c1-7-3-2-4-8-5-6-9(11)10(7)8/h2-4H,5-6H2,1H3

Upstream product

• 83586-04-3 7t-Methyl-(3arH,7atH)-3a,4,7,7a-tetrahydro-indanon-⁽¹⁾ 
• 39627-60-6 1-(2-methylphenyl)-2-propen-1-one 
• 74384-55-7 7-methylindan-1-ol 
• 3029-79-6 3-methylcinnamic acid 
• 118-90-1 ortho-methylbenzoic acid 
• 50-00-0 formaldehyd 
• 108-59-8 malonic acid dimethyl ester 
• 84450-90-8 2-methylbenzoic acid-6-d₁ 
• 3377-20-6 diethyl methylenemalonate 
• 78-94-4 methyl vinyl ketone 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 6968-35-0 7-hydroxy-indan-1-one 
• 868374-23-6 3-oxo-2,3-dihydro-1H-inden-4-yl trifluoromethanesulfonate 
• 544-97-8 dimethyl zinc(II) 

Downstream Products

• 7344-34-5 4-methyl-1H-indene 
• 461641-19-0 (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-methylindan-2-ol 
• 461641-11-2 5-methyl-4-phenyl-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester 
• 461641-23-6 1-{4-hydroxymethyl-6-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-3,6-dihydro-2H-pyridin-1-yl}-7-methyl-indan-2-ol 
• 461641-22-5 5-methyl-4-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester 
• 7251-82-3 3-Methylphthalimide 
• 1297598-92-5 2-(4-fluorobenzylidene)-7-methylindan-1-one 
• 1297598-96-9 [9-bromomethyl-4-(4-fluorophenyl)-5-oxo-5H-indeno[1,2-d]pyrimidin-2-yl]-bis-carbamic acid tert-butyl ester 
• 1297598-95-8 [4-(4-fluorophenyl)-9-methyl-5-oxo-5H-indeno[1,2-d]pyrimidin-2-yl]-bis-carbamic acid tert-butyl ester 
• 1297598-97-0 2-amino-9-bromomethyl-4-(4-fluoro-phenyl)-indeno[1,2-d]pyrimidin-5-one 
• 1297598-88-9 2-Amino-9-(2,4-dimethyl-thiazol-5-ylmethyl)-4-(4-fluoro-phenyl)-indeno[1,2-d]pyrimidin-5-one 
• 1297598-94-7 2-amino-4-(4-fluoro-phenyl)-9-methyl-indeno[1,2-d]pyrimidin-5-one 
• 1297598-93-6 4-(4-fluoro-phenyl)-9-methyl-5H-indeno[1,2-d]pyrimidin-2-ylamine 
• 113649-28-8 2-(3,5-Dimethoxybenzyl)-2,3-dihydro-2-(3-methoxy-5-methylbenzyl)-7-methyl-1H-inden-1-on 

Relevant articles and documents

Synthesis method of indanone derivatives

The present invention provides a synthesis method of indanone derivatives. The synthesis method comprises the following steps: adding a benzoic acid compound, an acrylate compound, a rhodium catalyst and an alkali to an organic solvent, heating under a nitrogen gas condition to carry out a reaction, and after the reaction is complete, carrying out post-treatment to obtain 2-substituted indanone compounds. According to the synthesis method of the indanone derivatives, one-step synthesis of the indanone products from the benzoic acid compound and the acrylic ester compound is realized; and the method is simple and convenient to operate, good in functional group compatibility and high in reaction yield.

Rh-Catalyzed Annulation of Benzoic Acids, Formaldehyde, and Malonates via ortho-Hydroarylation to Indanones

A three-component reaction from readily available low-cost materials of benzoic acids, formaldehyde, and malonates for the preparation of indanones by rhodium catalysis is reported. The annulation is initiated by an ortho-hydroarylation of benzoic acids, and a Lewis acid is not required. The solvent has a significant influence to the reaction, and 2-substituted or nonsubstituted indanones are obtained by the change of solvent.

Non-conventional methodologies in the synthesis of 1-indanones

1-Indanones have been successfully prepared by means of three different non-conventional techniques, namely microwaves, high-intensity ultrasound and a Q-tube reactor. A library of differently substituted 1-indanones has been prepared via one-pot intramolecular Friedel-Crafts acylation and their efficiency and "greenness" have been compared.