398-74-3

Basic information

• Product Name: o-chlorophenyl trifluoromethyl Sulfide
• Synonyms: 2-Chlorophenyl trifluoromethyl sulfide;1-chloro-2-[(trifluoromethyl)thio]-Benzene
• CAS NO: 398-74-3
• Molecular Formula: C7H4ClF3S
• Molecular Weight: 212.623
• Mol File: 398-74-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: o-chlorophenyl trifluoromethyl Sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: o-chlorophenyl trifluoromethyl Sulfide(398-74-3)
• EPA Substance Registry System: o-chlorophenyl trifluoromethyl Sulfide(398-74-3)

Safety Data

• Hazardous Substances Data: 398-74-3(Hazardous Substances Data)

Usage

General Description

O-chlorophenyl trifluoromethyl sulfide is a chemical compound that is used as a synthetic intermediate in the production of pharmaceuticals and agrochemicals. It is also used in the manufacturing of pesticides and can be found in products designed to control the growth of microorganisms. This chemical is a colorless to light brown liquid with a pungent odor and is considered to be moderately toxic if ingested or inhaled. It is important to handle o-chlorophenyl trifluoromethyl sulfide with care and follow proper safety precautions when working with this compound.

Upstream product

• 5375-05-3 <2-Chlor-phenyl>-trichlormethyl-sulfid 
• 6320-03-2 2-chlorothiphenol 
• 2314-97-8 iodotrifluoromethane 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 2926-29-6 Langlois reagent 
• 71-43-2 benzene 
• 421-17-0 Trifluoromethylsulfenyl chloride 
• 108-90-7 chlorobenzene 
• 456-56-4 phenyl trifluoromethylsulfide 
• 615-41-8 2-iodochlorobenzene 
• 3872-23-9 Copper(I) trifluoromethanethiolate 

Downstream Products

• 382-70-7 1-chloro-2-(trifluoromethylsulfonyl)benzene 
• 387-93-9 (2-chloro-4-nitro-phenyl)-trifluoromethyl sulfoxide 
• 32858-96-1 2-Hydroxyphenyltrifluoromethylsulphone 
• 2358-41-0 1-fluoro-2-[(trifluoromethyl)sulfonyl]benzene 

Relevant articles and documents

Commercial-Scale Visible Light Trifluoromethylation of 2-Chlorothiophenol Using CF3I Gas

Despite the growth of photoredox methods in academia, application of photoredox at scale in the pharmaceutical and fine chemical industries has been slow. In this report, a photoredox trifluoromethylation of a thiophenol was modified from the original literature report, and the mechanism was investigated to define the key scale-up parameters. The mechanistic insight was leveraged in the design and execution of two different reactor designs: an LED-based plug flow photoreactor and a laser-based continuous stirred tank photoreactor. In one of the first examples of commercial-scale photoredox chemistry, the process was scaled to provide over 500 kg of the desired intermediate and amended to fully continuous manufacturing.

Silver-catalyzed fluoroalkylation of thiols using fluoroalkanesulfinates

A practical sliver-catalyzed fluoroalkylation of aryl-, heteroaryl- and alkylthiols has been developed. The reaction has a good functional-group tolerance and excellent selectivity. A variety of stable and solid fluoroalkanesulfinates including di- and perfluoroalkanesulfinates can be employed. This methodology provides a straightforward and streamlined access to perfluoroalkylthiolated organic molecules. [Figure presented]

PREPARATION AND FLUORINATION OF ARYLTRIFLUOROMETHYLSULPHONES

A series of chloro- and nitrophenyl trifluoromethyl sulphides and sulphones have been synthesised from the corresponding aryl halides .The fluorination of these compounds by tetra-n-butyl ammonium fluoride and potassium fluoride has been investigated.Our results show that generally they are more susceptible to fluorodenitration than fluorodechlorination.