39856-58-1 Usage
Description
3-Amino-2-bromopyridine is an organic compound with the molecular formula C5H5BrN2. It is a light yellow crystalline substance that is commonly used as a building block in the synthesis of various heterocyclic compounds. Its chemical structure features a pyridine ring with a bromine atom at the 2nd position and an amino group at the 3rd position, which makes it a versatile intermediate for chemical reactions and pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
3-Amino-2-bromopyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the formation of a wide range of fused mediumand large-ring heterocycles, which are essential in the development of new drugs with diverse therapeutic properties.
Used in Chemical Synthesis:
3-Amino-2-bromopyridine is used as a starting material for the preparation of pyrrole derivatives, which are important components in the synthesis of various organic compounds and materials. Its reactivity and functional groups make it a valuable building block for the development of novel chemical structures with potential applications in various industries.
Used in P-C Coupling Reaction:
3-Amino-2-bromopyridine is employed in P-C coupling reactions, which are essential for the formation of carbon-phosphorus bonds in organic compounds. This type of reaction is widely used in the synthesis of complex molecules, including those with potential applications in the pharmaceutical, agrochemical, and materials science industries.
Used in Palladium-Catalyzed Synthesis:
3-Amino-2-bromopyridine is utilized in palladium-catalyzed synthesis, a widely used method for the formation of carbon-carbon and carbon-heteroatom bonds. This reaction is particularly useful for the synthesis of indole systems containing fused mediumand large-ring heterocycles, which are important structural motifs in various biologically active compounds and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 39856-58-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,8,5 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 39856-58:
(7*3)+(6*9)+(5*8)+(4*5)+(3*6)+(2*5)+(1*8)=171
171 % 10 = 1
So 39856-58-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H5BrN2/c6-5-4(7)2-1-3-8-5/h1-3H,7H2
39856-58-1Relevant articles and documents
A High-Throughput Assay for Arylamine Halogenation Based on a Peroxidase-Mediated Quinone-Amine Coupling with Applications in the Screening of Enzymatic Halogenations
Hosford, Joseph,Shepherd, Sarah A.,Micklefield, Jason,Wong, Lu Shin
supporting information, p. 16759 - 16763 (2016/02/12)
Arylhalides are important building blocks in many fine chemicals, pharmaceuticals and agrochemicals, and there has been increasing interest in the development of more "green" halogenation methods based on enzyme catalysis. However, the screening and development of new enzymes for biohalogenation has been hampered by a lack of high-throughput screening methods. Described herein is the development of a colorimetric assay for detecting both chemical and enzymatic arylamine halogenation reactions in an aqueous environment. The assay is based on the unique UV/Vis spectrum created by the formation of an ortho-benzoquinone-amine adduct, which is produced by the peroxidase-catalysed benzoquinone generation, followed by Michael addition of either a halogenated or non-halogenated arylamine. This assay is sensitive, rapid and amenable to high-throughput screening platforms. We have also shown this assay to be easily coupled to a flavin-dependent halogenase, which currently lacks any convenient colorimetric assay, in a "one-pot" workflow.
NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND
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Page/Page column 71, (2010/11/08)
The present invention provides an antifungal agent represented by the formula: [wherein A1 represents a 3-pyridyl group which may have a substituent, a quinolyl group which may have a substituent, or the like; X1 represents a group represented by the formula -NH-C(=O)-, a group represented by the formula -C(=O)-NH-, or the like; E represents a furyl group, a thienyl group, a pyrrolyl group, a phenyl group, a pyridyl group, a tetrazolyl group, a thiazolyl group or a pyrazolyl group; with the proviso that A1 may have 1 to 3 substituents, and E has one or two substituents].
Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
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, (2008/06/13)
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.