39890-98-7

Basic information

• Product Name: 2,6-Dichloro-4-(trifluoromethyl)pyridine
• Synonyms: 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE;4-TRIFLUOROMETHYL-2,6-DICHLOROPYRIDINE;4-TrifluoroMethyl-2,6-dichloroprydine;2,6-Dichloro-alpha,alpha,alpha-trifluoro-4-picoline
• CAS NO: 39890-98-7
• Molecular Formula: C₆H₂Cl₂F₃N
• Molecular Weight: 215.99
• EINECS: 201-525-2
• Product Categories: Pyridines;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building BlocksHeterocyclic Building Blocks;New Products for Chemical Synthesis;Aromatics;Heterocycles;Intermediates;Fluorine series
• Mol File: 39890-98-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 85°C 40mm
• Flash Point: 70-75°C/25mm
• Appearance: /
• Density: 1.505 g/mL at 25 °C
• Vapor Pressure: 0.594mmHg at 25°C
• Refractive Index: n20/D 1.473
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -4.51±0.10(Predicted)
• CAS DataBase Reference: 2,6-Dichloro-4-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-4-(trifluoromethyl)pyridine(39890-98-7)
• EPA Substance Registry System: 2,6-Dichloro-4-(trifluoromethyl)pyridine(39890-98-7)

Safety Data

• Hazard Codes: T,F,Xi
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• RIDADR: UN2810
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 39890-98-7(Hazardous Substances Data)

Usage

Description

2,6-Dichloro-4-(trifluoromethyl)pyridine is a tri-substituted pyridine compound characterized by the presence of two chlorine atoms at the 2nd and 6th positions and a trifluoromethyl group at the 4th position. This organic molecule serves as a key intermediate in the synthesis of various pharmaceutical agents.

Uses

Used in Pharmaceutical Industry:
2,6-Dichloro-4-(trifluoromethyl)pyridine is used as a key intermediate in the synthesis of pharmaceutical agents for its potential antitumor activities. Its unique structural features allow for the development of compounds that can target and inhibit specific molecular pathways involved in tumor growth and progression, offering a promising avenue for the creation of novel cancer therapeutics.

InChI:InChI=1/C6H4FNO/c7-6-1-5(4-9)2-8-3-6/h1-4H

Upstream product

• 4759-65-3 3-(trifluoromethyl)glutaric anhydride 
• 4162-55-4 3-(trifluoromethyl)pentanedioic acid 
• 339539-96-7 3-hydroxy-3-trifluoromethyl-1,5-pentanedialdehyde 
• 36610-31-8 3-hydroxy-3-trifluoromethyl-1,5-pentanedicarboxylic acid 
• 36610-32-9 4-hydroxy-4-trifluoromethyl-1,6-heptadiene 
• 356518-29-1 4-trifluoromethyl-2,6-piperidinedione 
• 339539-97-8 4-trifluoromethyl-3H-pyridine-2,6-dione 

Downstream Products

• 326894-74-0 2-iodo-4-(trifluoromethyl)pyridine 
• 100366-76-5 2,6-diiodo-4-(trifluoromethyl)pyridine 
• 862120-74-9 2-(2-nitrophenyl)sulfonyl-8-(trifluoromethyl)-3,4-dihydro-1H-pyrido[1,2-a]pyrazin-6-one 
• 862120-73-8 N-(2-bromoethyl)-2-nitro-N-[[6-oxo-4-(trifluoromethyl)-1H-pyridin-2-yl]methyl]benzenesulfonamide 
• 862120-72-7 N-(2-bromoethyl)-N-[[6-tert-butoxy-4-(trifluoromethyl)-2-pyridyl]methyl]-2-nitrobenzenesulfonamide 
• 1160994-99-9 2-chloro-6-methoxy-4-(trifluoromethyl)pyridine 
• 165385-89-7 6-methyl-4-(trifluoromethyl)pyridin-2-amine 
• 34486-23-2 6-chloro-4-(trifluoromethyl)pyridin-2-amine 
• 106447-97-6 2-amino-4-(trifluoromethyl)pyridine 

Relevant articles and documents

SUBSTITUTED AZOLE DIONE COMPOUNDS WITH ANTIVIRAL ACTIVITY

Provided herein are methods of using substituted azole dione compounds for treatment of viral infections.

Synthesis of novel analogues of marine indole alkaloids: Mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines as potential anticancer agents

Mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines were synthesized using Suzuki cross-coupling reaction between 2-chloro-4-trifluoromethylpyridine 9, 2,6-dichloro-4-trifluoromethylpyridine 6 or 2,6-dichloro-3-cyano-4-tri

Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines

A series of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines was designed and synthesized as potential antitumor agents. They were evaluated for preliminary cytotoxic activity against P388 and A-549 cells with IC50 values. 4-Trifluoromethyl-2,6-bis[3′-(N-tosyl-6′-methoxyl-indolyl)] pyridine was identified as the most potent in this series.