39891-04-8

Basic information

• Product Name: 3-FLUORO-5-FORMYLPYRIDINE
• Synonyms: 5-FLUOROPYRIDINE-3-CARBALDEHYDE;3-PYRIDINECARBOXALDEHYDE, 5-FLUORO-;3-FLUORO-5-FORMYLPYRIDINE;3-Fluoropyridine-5-carboxaldehyde;3-Pyridinecarboxaldehyde,5-fluoro-(9CI);5-Fluoronicotinaldehyde;3-fluorine-5-formylpyridine;5-Fluoropyridine-3-carboxaldehyde, 5-Fluoro-3-formylpyridine, 3-Fluoro-5-formylpyridine, 3-Fluoropyridine-5-carboxaldehyde
• CAS NO: 39891-04-8
• Molecular Formula: C₆H₄FNO
• Molecular Weight: 125.1
• EINECS: 206-914-8
• Product Categories: PYRIDINE;pharmacetical;Aldehyde;Building Blocks;Pyridines;Fluorine series;organic building block
• Mol File: 39891-04-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 189℃
• Flash Point: 68℃
• Appearance: /
• Density: 1.269
• Vapor Pressure: 0.0362mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.01±0.20(Predicted)
• CAS DataBase Reference: 3-FLUORO-5-FORMYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-5-FORMYLPYRIDINE(39891-04-8)
• EPA Substance Registry System: 3-FLUORO-5-FORMYLPYRIDINE(39891-04-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 39891-04-8(Hazardous Substances Data)

Usage

General Description

3-Fluoro-5-formylpyridine is a chemical compound with the molecular formula C6H4NO, containing a pyridine ring with a fluorine atom at the 3-position and a formyl group at the 5-position. It is commonly used as a building block in organic synthesis, particularly in the pharmaceutical and agrochemical industries. 3-FLUORO-5-FORMYLPYRIDINE has the potential to be used as an intermediate in the production of various active pharmaceutical ingredients as well as in the development of new pesticides. Additionally, 3-fluoro-5-formylpyridine is also being studied for its potential applications in medicinal chemistry and drug discovery due to its unique chemical structure and reactivity.

InChI:InChI=1/C9H6F3NS/c1-5-13-7-4-6(9(10,11)12)2-3-8(7)14-5/h2-4H,1H3

Upstream product

• 701-40-6 5-fluoropyridine-3-carbohydrazide 
• 455-70-9 5-fluoro-3-pyridinecarboxylic acid methyl ester 
• 402-66-4 5-fluoropyridine-3-carboxylic acid 
• 3222-49-9 5-methylnicotinic acid 
• 3430-19-1 5-methylpyridin-3-amine 
• 407-21-6 5-methyl-3-fluoropyridine 
• 591-22-0 3,5-Lutidine 
• 22620-29-7 Ethyl 5-fluoronicotinate 
• 107756-01-4 C₁₃H₁₂FN₃O₃S 
• 22620-32-2 (5-fluoropyridin-3-yl)methanol 
• 884494-95-5 5-methyl-nicotinic acid chloride 
• 70-57-5 5-methylpyridinylcarboxamide 

Downstream Products

• 114995-63-0 (2-Amino-3,5-difluoro-phenyl)-(5-fluoro-pyridin-3-yl)-methanone 
• 1426899-73-1 2-(5-fluoro-pyridin-3-yl)-6-hydroxy-chroman-4-one 
• 1426899-72-0 (E)-1-(2,5-dihydroxy-phenyl)-3-(5-fluoro-pyridin-3-yl)propenone 
• 1095380-88-3 tert-butyl 4-(4-(6-bromo-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate 
• 1095380-99-6 tert-butyl 4-(4-(6-bromo-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-jb]pyridin-2-yl)phenyl)piperazine-1-carboxylate 
• 1095381-08-0 tert-butyl 4-(4-(6-chloro-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)piperazine-1-carboxylate 
• 1095380-89-4 6-bromo-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridine 
• 1095380-95-2 tert-butyl-4-(6-bromo-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl carbamate 
• 1095381-11-5 tert-butyl 4-(6-chloro-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzylcarbamate 
• 1095381-05-7 6-bromo-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridine 
• 1095381-10-4 6-chloro-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-2-(4-(piperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridine 
• 1095380-92-9 2-(4-(6-bromo-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy)-N,N-dimethylethanamine 
• 1095380-90-7 2-(4-(6-bromo-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy)ethanol 
• 1095381-12-6 (4-(6-chloro-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)methanamine 

Relevant articles and documents

PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS

PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula (I): wherein R1, R2 R 3 and R4 are as defined herein.

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

A new series of 3-(3-pyridyl)acrylamides 16, 17, 19, and 26, and 5-(3-pyridyl)-2,4-pentadienamides 20-25 were prepared and evaluated for their antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compounds 1a [(E)-N-[4 [4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamide] against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, 4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide (17p) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.