400614-05-3

Basic information

• Product Name: CYCLOPROPYL 2-METHOXYPHENYL KETONE
• Synonyms: CYCLOPROPYL 2-METHOXYPHENYL KETONE;cyclopropyl(2-methoxyphenyl)methanone
• CAS NO: 400614-05-3
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• Mol File: 400614-05-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 277.492°C at 760 mmHg
• Flash Point: 121.159°C
• Appearance: /
• Density: 1.142g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: CYCLOPROPYL 2-METHOXYPHENYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPROPYL 2-METHOXYPHENYL KETONE(400614-05-3)
• EPA Substance Registry System: CYCLOPROPYL 2-METHOXYPHENYL KETONE(400614-05-3)

Safety Data

• Hazardous Substances Data: 400614-05-3(Hazardous Substances Data)

Usage

General Description

CYCLOPROPYL 2-METHOXYPHENYL KETONE, also known as 2-Cyclopropyl-2-methoxyacetophenone, is a chemical compound with the molecular formula C11H12O2. It is a ketone with a cyclopropyl group and a methoxyphenyl group attached to the carbonyl carbon. This chemical is commonly used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a building block in the production of fragrance and flavor ingredients. Additionally, CYCLOPROPYL 2-METHOXYPHENYL KETONE has potential applications in the field of material science and as an intermediate in organic synthesis.

InChI:InChI=1/C11H12O2/c1-13-10-5-3-2-4-9(10)11(12)8-6-7-8/h2-5,8H,6-7H2,1H3

Upstream product

• 854304-53-3 cyclopropyl-(2-methoxy-phenyl)-ketone-imine 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 578-57-4 2-bromoanisole 
• 5500-21-0 cyclopropropanecarbonitrile 

Downstream Products

• 444149-33-1 cyclopropanecarboxylic acid o-anisidide 
• 1355988-71-4 α-cyclopropyl-2-methoxystyrene 
• 58713-52-3 2'-methoxy-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one 
• 1196851-96-3 5-[(E)-2-cyclopropyl-2-(2'-methoxyphenyl)vinyl]furo-[2,3-d]pyrimidine-2,4-diamine 

Relevant articles and documents

Ni/Ti Dual Catalytic Cross-Coupling of Nitriles and Organobromides to Access Ketones

Herein, we report the development of a dual catalytic approach for the cross-coupling of nitriles with aryl- and aliphatic-bromides. A titanium(III) catalyst is used to activate nitriles enabling their coupling with organobromides through a nickel catalyst. The Ni/Ti system efficiently prepared unsymmetrical ketones with good chemoselectivity and could selectively couple a bromide in the presence of other functionalizable handles.

Calcium receptor antagonist

A compound of the formula [I] wherein R1 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 cycloalkyl group and the like; R3 is hydrogen atom, C1-6 alkyl group, hydroxyl group and the like; R4 is hydrogen atom, C1-6 alkyl group and the like; R5 and R6 are each C1-6 alkyl group and the like; R7 is optionally substituted aryl group or optionally substituted heteroaryl group; X1, X2 and X3 are each C1-6 alkylene group and the like; and X4 and X5 are each a single bond, methylene group and the like, a salt thereof, a solvate thereof or a prodrug thereof, and a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic agent for osteoporosis, are provided. The compound of the present invention is useful as a therapeutic drug of diseases accompanied by abnormal calcium homeostasis, or osteoporosis, hypoparathyreosis, osteosarcoma, periodontal disease, bone fracture, steoarthrosis, chronic rheumatoid arthritis, Paget's disease, humoral hypercalcemia, autosomal dominant hypocalcemia and the like. In addition, an intermediate for the compound is provided.