40101-61-9

Basic information

• Product Name: 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile
• Synonyms: 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile
• CAS NO: 40101-61-9
• Molecular Formula: C₁₅H₈N₂O₂
• Molecular Weight: 248.23622
• Mol File: 40101-61-9.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile(40101-61-9)
• EPA Substance Registry System: 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile(40101-61-9)

Safety Data

• Hazardous Substances Data: 40101-61-9(Hazardous Substances Data)

Upstream product

• 13475-43-9 2-(4-(1,3-dioxoisoindolin-2-yl)phenyl)acetic acid 
• 64-18-6 formic acid 
• 81654-64-0 N-(4-cyanophenyl)-2-iodo-benzamide 
• 609-67-6 2-Iodobenzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 
• 1074-82-4 potassium phtalimide 
• 873-74-5 4-Aminobenzonitrile 
• 85-44-9 phthalic anhydride 
• 136918-14-4 phthalimide 
• 126747-14-6 4-cyanophenylboronic acid 
• 615-42-9 1,2-Diiodobenzene 
• 201230-82-2 carbon monoxide 
• 303768-59-4 N-(4-cyano-phenyl)-phthalamic acid 

Relevant articles and documents

Ru-Catalyzed Selective C-H Bond Hydroxylation of Cyclic Imides

We report on cyclic imides as weak directing groups for selective monohydroxylation reactions using ruthenium catalysis. Whereas acyclic amides are known to promote the hydroxylation of the C(sp2)-H bond enabling five-membered ring ruthenacycle intermediates, the cyclic imides studied herein enabled the hydroxylation of the C(sp2)-H bond via larger six-membered ruthenacycle intermediates. Furthermore, monohydroxylated products were exclusively obtained (even in the presence of overstoichiometric amounts of reagents), which was rationalized by the difficulty to accommodate coplanar intermediates once the first hydroxyl group was introduced into the substrate. The same reactivity was observed in the presence of palladium catalysts.

Imide arylation with aryl(TMP)iodonium tosylates

Herein, we describe the synthesis of N-aryl phthalimides by metal-free coupling of potassium phthalimide with unsymmetrical aryl(TMP)iodonium tosylate salts. The aryl transfer from the iodonium moiety occurs under electronic control with the electron-rich trimethoxyphenyl group acting as a competent dummy ligand. The yields of N-aryl phthalimides are moderate to high and the coupling reaction is compatible with electron-deficient and sterically encumbered aryl groups.

Comparison of copper(II) acetate promoted N-arylation of 5,5-dimethyl hydantoin and other imides with triarylbismuthanes and aryl boronic acids

This work demonstrates that the copper acetate promoted N-arylation of imides with boronic acids can be employed as a major method for the synthesis of N3-aryl hydantoins. Georg Thieme Verlag Stuttgart.