40143-27-9

Basic information

• Product Name: 4-BIPHENYLALDEHYDE OXIME
• Synonyms: 4-BIPHENYLALDEHYDE OXIME;4-PHENYLBENZALDEHYDE OXIME;4-PHENYLBENZALDOXIME;P-PHENYLBENZALDOXIME
• CAS NO: 40143-27-9
• Molecular Formula: C₁₃H₁₁NO
• Molecular Weight: 197.23
• Product Categories: Biphenyl derivatives;Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 40143-27-9.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 334.8°Cat760mmHg
• Flash Point: 206.9°C
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 4.92E-05mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 4-BIPHENYLALDEHYDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BIPHENYLALDEHYDE OXIME(40143-27-9)
• EPA Substance Registry System: 4-BIPHENYLALDEHYDE OXIME(40143-27-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 40143-27-9(Hazardous Substances Data)

Usage

Description

4-BIPHENYLALDEHYDE OXIME is an organic compound derived from the oximation of 4-BIPHENYLALDEHYDE. It is characterized by its unique chemical structure, which features a carbon-nitrogen double bond (C=N-OH) and a biphenyl group. 4-BIPHENYLALDEHYDE OXIME is known for its potential applications in various fields due to its reactive nature and structural properties.

Uses

Used in Pharmaceutical Industry:
4-BIPHENYLALDEHYDE OXIME is used as a reactant for the design and synthesis of substituted-isoxazole derivatives. These derivatives serve as farnesoid X receptor (FXR) antagonists, which play a crucial role in the treatment of various diseases, including liver and metabolic disorders.
Used in Chemical Synthesis:
In the field of organic chemistry, 4-BIPHENYLALDEHYDE OXIME is utilized as an intermediate in the synthesis of various complex molecules and compounds. Its unique structure allows for further functionalization and modification, making it a valuable building block in the development of new chemical entities with potential applications in different industries.
Used in Research and Development:
4-BIPHENYLALDEHYDE OXIME is also employed in research and development settings, where it is used to study the properties and reactivity of oxime-containing compounds. This helps scientists and researchers to better understand the underlying mechanisms and develop new strategies for the synthesis of novel molecules with specific applications.

InChI:InChI=1/C13H11NO/c15-14-10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-10,15H/b14-10-

Upstream product

• 92-66-0 4-bromo-1,1'-biphenyl 
• 68-12-2 N,N-dimethyl-formamide 
• 3597-91-9 biphenyl-4-yl methanol 
• 2920-38-9 4-cyano-1,1'-biphenyl 
• 3218-36-8 4-Phenylbenzaldehyde 

Downstream Products

• 3218-36-8 4-Phenylbenzaldehyde 
• 6301-56-0 ethyl 4-phenylbenzoate 
• 720-75-2 methyl 4-phenylbenzoate 
• 2920-38-9 4-cyano-1,1'-biphenyl 
• 55667-08-8 3,5-bis-biphenyl-4-yl-[1,2,4]oxadiazole 
• 51813-19-5 3-([1,1'-biphenyl]-4-yl)-5-phenylisoxazole 
• 40019-44-1 N′-hydroxy-[1,1′-biphenyl]-4-carboximidamide 
• 2562-77-8 2-([1,1′-biphenyl]-4-yl)-1H-benzo[d]imidazole 

Relevant articles and documents

HCl-mediated cascade cyclocondensation of oxygenated arylacetic acids with arylaldehydes: one-pot synthesis of 1-arylisoquinolines

In this paper, a concise, open-vessel synthesis of 1-arylisoquinolines is describedviaHCl-mediated intermolecular cyclocondensation of oxygenated arylacetic acids with arylaldehydes in the presence of NH2OH and alcoholic solvents under mild and one-pot reaction conditions. A plausible mechanism is proposed and discussed herein. In the overall reaction process, only water was generated as the byproduct. Various environmentally friendly reaction conditions are investigated for convenient transformationviathe (4C + 1C + 1N) annulation. This protocol provides a highly effective ring closureviathe formations of one carbon-carbon (C-C) bond, two carbon-nitrogen (C-N) bonds and one carbon-oxygen (C-O) bond.

SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)

A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.

A Transition-Metal-Free One-Pot Cascade Process for Transformation of Primary Alcohols (RCH2OH) to Nitriles (RCN) Mediated by SO2F2

A new transition-metal-free one-pot cascade process for the direct conversion of alcohols to nitriles was developed without introducing an “additional carbon atom”. This protocol allows transformations of readily available, inexpensive, and abundant alcohols to highly valuable nitriles.