4015-28-5

Basic information

• Product Name: 6-chloro-4-phenylquinazoline
• Synonyms: 6-chloro-4-phenylquinazoline
• CAS NO: 4015-28-5
• Molecular Formula: C₁₄H₉ClN₂
• Molecular Weight: 240.68766
• Mol File: 4015-28-5.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-chloro-4-phenylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-4-phenylquinazoline(4015-28-5)
• EPA Substance Registry System: 6-chloro-4-phenylquinazoline(4015-28-5)

Safety Data

• Hazardous Substances Data: 4015-28-5(Hazardous Substances Data)

Usage

Description

6-Chloro-4-phenylquinazoline is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes a quinazoline ring with a chloro substituent at the 6th position and a phenyl group at the 4th position.

Uses

Used in Pharmaceutical Industry:
6-Chloro-4-phenylquinazoline is used as a key intermediate in the synthesis of 6-chloro1,4-dihydro-1-methyl-4-phenyl-4-quinazolinol (C371025), a compound with potential therapeutic applications. Its role in the pharmaceutical industry is to facilitate the development of new drugs by providing a building block for the creation of more complex molecules with specific biological activities.

Upstream product

• 136440-59-0 (Z)-2-Amino-5-chlorbenzophenonamidinohydrazon-acetat 
• 136440-60-3 (E)-2-Amino-5-chlorbenzophenonamidinohydrazon-acetat 
• 5958-08-7 6-chloro-4-phenylquinazoline-2-carboxylic acid 
• 153681-82-4 6-chloro-1,2-dihydro-4-phenylquinazoline-2-carboxylic acid 
• 27610-14-6 3-amino-6-chloro-3,4-dihydro-4-hydroxy-4-phenylquinazoline 
• 4016-85-7 5-chloro-2-(chloroacetylamino)benzophenone 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 88190-77-6 6-chloro-3,4-dihydro-4-phenylquinazoline-2-carboxylic acid 
• 50-00-0 formaldehyd 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 20028-53-9 2-amino-5-chlorobenzaldehyde 
• 516-06-3 D,L-valine 
• 2835-06-5 phenylglycin 
• 56-40-6 glycine 

Downstream Products

• 13132-91-7 1-(6-chloro-4-phenylquinazolin-2-yl)ethan-1-one 

Relevant articles and documents

Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines

A one-pot method for joining three separate components leading to an assortment of 4-arylquinazolines (27 examples) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed?-cascade reaction involving C(sp)-C(sp 2/s

4-arylquinazoline compounds and preparation method thereof

The invention provides 4-arylquinazoline compounds which have a general formula as shown in the specification, wherein R represents hydrogen, halogen, alkane, nitro or alkoxy, R represents hydrogen or methyl, Ar represents groups as shown in the specification, and R represents hydrogen, halogen, alkane, alkoxy, nitro, hydroxy, trifluoromethyl, phenyl or methoxycarbonyl; the compounds enrich the structures of 4-arylquinazoline compounds, and provide a material basis for further study on the potential biological activity of the compounds. The invention also provides a preparation methodof the compounds, which comprises the following step: cyanophenyl raw materials react with aromatic phenylboronic acid ArB(OH)2 in a sealed environment under the action of a palladium salt catalyst,a bidentate chelating ligand, a Lewis acid and a solvent at 30-300 DEG C to form the 4-arylquinazoline compounds; a structural formula of the 4-arylquinazoline compounds is shown in the specification,and the preparation method provided by the invention has the advantages of no need of inert gas protection, mild reaction conditions, short reaction time, high yield and the like.

Silver-Catalyzed Isocyanide Insertion into N?H Bond of Ammonia: [5+1] Annulation to Quinazoline Derivatives

A silver-catalyzed [5+1] annulation of o-acylaryl isocyanides with ammonium acetate and hydroxlamine was developed for the efficient and practical synthesis of quinazolines and quinazoline 3-oxides in good to excellent yields, respectively. The domino process involved an unprecedented isocyanide insertion into the N?H bond of ammonia or hydroxylamine and followed by condensation reaction at ambient conditions. (Figure presented.).