40179-50-8

Basic information

• Product Name: Piperidine, 1-(4-nitrobenzoyl)-2-(3-pyridinyl)-, (S)-
• CAS NO: 40179-50-8
• Molecular Formula: C17H17N3O3
• Molecular Weight: 311.34
• Mol File: 40179-50-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-(4-nitrobenzoyl)-2-(3-pyridinyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-(4-nitrobenzoyl)-2-(3-pyridinyl)-, (S)-(40179-50-8)
• EPA Substance Registry System: Piperidine, 1-(4-nitrobenzoyl)-2-(3-pyridinyl)-, (S)-(40179-50-8)

Safety Data

• Hazardous Substances Data: 40179-50-8(Hazardous Substances Data)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 494-52-0 Anabasine 
• 53912-89-3 (2S)-2-(3-pyridyl)piperidine hydrochloride 
• 500-22-1 3-pyridinecarboxaldehyde 
• 337974-47-7 5-[(4'-methylphenyl)sulfonyl]-1-(3'-pyridyl)-1-penten-3-one 
• 337974-58-0 (2S)-N-[(1S)-1-phenylethyl]-2-(3-pyridyl)-4-piperidine 
• 337974-55-7 (2S)-N-[(1S)-1-phenylethyl]-2-(3-pyridyl)-4-piperidone 
• 337974-57-9 (S)-8-((S)-1-Phenyl-ethyl)-7-pyridin-3-yl-1,4-dithia-8-aza-spiro[4.5]decane 
• 121675-95-4 2,2-Dimethyl-propionic acid (2R,3R,4S,5S,6R)-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-2-(S)-3,4,5,6-tetrahydro-2H-[2,3']bipyridinyl-1-yl-tetrahydro-pyran-3-yl ester 
• 121675-93-2 2,2-Dimethyl-propionic acid (2R,3R,4S,5S,6R)-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-2-((S)-4-oxo-3,4,5,6-tetrahydro-2H-[2,3']bipyridinyl-1-yl)-tetrahydro-pyran-3-yl ester 
• 122294-65-9 2,2-Dimethyl-propionic acid (2R,3R,4S,5S,6R)-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-2-((S)-7-pyridin-3-yl-1,4-dithia-8-aza-spiro[4.5]dec-8-yl)-tetrahydro-pyran-3-yl ester 
• 141120-47-0 benzyl-pyridin-3-ylmethylene-amine 
• 31944-77-1 (2S)-N-benzyl-2-(3-pyridyl)-piperidine 
• 141120-48-1 (2S)-N-benzyl-2,3-dihydro-2-(3-pyridyl)-4-pyridone 

Downstream Products

• 494-52-0 Anabasine 

Relevant articles and documents

Enantioselective syntheses of 2-alkyl-, 2,6-dialkylpiperidines and indolizidine alkaloids through diastereoselective Mannich-Michael reactions

Aldimines of 2,3,4,6-tetra-O-pivaloyl-β-D-galactosylamine react with 1-methoxy-3-trimethylsilyloxybuta-1,3-diene in a Mannich-Michael condensation reaction sequence to give 2-substituted N-galactosyl-5,6-dehydropiperidin-4-ones 3 with high diastereoselectivity. The X-ray analysis of the 2-propyl derivative 3a proved (R)-configuration of the major diastereomer and led to the correction of our earlier assignment of configuration for (-)-coniine hydrochloride 9a obtained from this intermediate. Despite their low reactivity, these enaminones 3 can be converted into chiral 2,6-cis-disubstituted piperidinones 12 with high stereoselectivity by reaction with organocuprates in combination with hard electrophiles. Enantiomerically pure alkaloids such as (-)-dihydropinidine and gephyrotoxine 167B have been synthesized according to this methodology.

4-[(4'-Methylphenyl)sulfonyl]-1-(trophenylphosphoranylidene)-2-butanone as a New Four-Carbon Synthon for Substituted Divinyl Ketones

The title compound and the corresponding anion have been conveniently used as precursors of substituted divinylketones in both carbo- and heterocyclization reactions in one-pot, three-step sequences leading to a wide variety of substituted carbo- and heterocyclic ring systems, as well as to multifunctionalized linear carbon frameworks. The compounds generated through the use of this multi-coupling reagent represent useful synthons for the construction of natural compounds including (+/-)-epibatidine, (-)-anabasine and (+/-)-pyrenophorin.