402741-05-3

Basic information

• Product Name: 2-Butanone, 3-hydroxy-4-[(4-methoxyphenyl)amino]-4-phenyl-, (3S,4R)-
• CAS NO: 402741-05-3
• Molecular Formula: C17H19NO3
• Molecular Weight: 285.343
• Mol File: 402741-05-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 3-hydroxy-4-[(4-methoxyphenyl)amino]-4-phenyl-, (3S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 3-hydroxy-4-[(4-methoxyphenyl)amino]-4-phenyl-, (3S,4R)-(402741-05-3)
• EPA Substance Registry System: 2-Butanone, 3-hydroxy-4-[(4-methoxyphenyl)amino]-4-phenyl-, (3S,4R)-(402741-05-3)

Safety Data

• Hazardous Substances Data: 402741-05-3(Hazardous Substances Data)

Upstream product

• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 116-09-6 hydroxy-2-propanone 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 402741-11-1 (4R,5S)-5-acetoxy-2-oxo-4-phenyloxazolidine-3-carboxylic acid tert-butylester 
• 402741-09-7 (4R,5S)-5-acetyl-2-oxo-4-phenyloxazolidine-3-carboxylic acid tert-butyl ester 
• 67341-01-9 (R)-N-(tert-butoxycarbonyl)phenylglycinol 
• 117049-14-6 tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate 
• 402741-08-6 (4R,5S)-5-acetyl-3-(4-methoxyphenyl)-4-phenyloxazolidin-2-one 

Relevant articles and documents

Proline catalyzed two-component, three-component and self-asymmetric Mannich reactions promoted by ultrasonic conditions

The proline catalyzed two-component and three-component asymmetric Mannich reaction with hydroxyacetone and self-Mannich reaction with propanal were performed successfully under ultrasonic conditions in 1 h to afford Mannich products in 90-98% isolated yi

Efficient catalysts for asymmetric Mannich reactions

Efficient chiral catalysts for direct asymmetric three-component Mannich reactions of ketones, aldehydes and an amine (p-anisidine) have been developed. The corresponding β-amino carbonyl compounds (Mannich adducts) were obtained in good chemical yields a

2-pyrrolidinecarboxylic acid ionic liquid as a highly efficient organocatalyst for the asymmetric one-pot Mannich reaction

A. novel one-pot: three-component asymmetric Mannich reaction using [EMIm][PrO] (1) as a catalyst has been developed. By employing this new reaction system, a variety of optically active ss-amino carbonyl compounds were synthesized in up to 99% yield with up to >99 dr and >99% ee. The reaction conditions have been optimized and the mechanism for the asymmetric induction is discussed.