403-46-3

Basic information

• Product Name: 4-FLUORO-N,N-DIMETHYLANILINE
• Synonyms: 4-FLUORO-N,N-DIMETHYLANILINE;N,N-DIMETHYL-4-FLUOROANILINE;(4-Fluoro-phenyl)-dimethyl-amine;Benzenamine,4-fluoro-N,N-dimethyl-;fluorodimethylaniline;p-Fluoro-N,N-dimethylaniline;NISTC403463;4-FLUORO-N,N-DIMETHYLANILINE 98+%
• CAS NO: 403-46-3
• Molecular Formula: C₈H₁₀FN
• Molecular Weight: 139.17
• Mol File: 403-46-3.mol
• Article Data: 56

Chemical Properties

• Melting Point: 36 °C
• Boiling Point: 200 °C
• Flash Point: 67.5 °C
• Appearance: /
• Density: 1.057 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-FLUORO-N,N-DIMETHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-N,N-DIMETHYLANILINE(403-46-3)
• EPA Substance Registry System: 4-FLUORO-N,N-DIMETHYLANILINE(403-46-3)

Safety Data

• Hazardous Substances Data: 403-46-3(Hazardous Substances Data)

Usage

General Description

4-FLUORO-N,N-DIMETHYLANILINE is a chemical compound with the molecular formula C8H10FN. It is characterized by the presence of a fluorine atom, two methyl groups, and an aniline moiety. 4-FLUORO-N,N-DIMETHYLANILINE is commonly used as an intermediate for the synthesis of various pharmaceuticals, dyes, and agrochemicals. It is also used as a reagent in organic chemical reactions. 4-FLUORO-N,N-DIMETHYLANILINE is a colorless to pale yellow liquid at room temperature and has a slightly sweet odor. It is important to handle this compound with caution, as it may be harmful if ingested, inhaled, or absorbed through the skin.

Upstream product

• 67-68-5 dimethyl sulfoxide 
• 350-46-9 4-Fluoronitrobenzene 
• 67-56-1 methanol 
• 371-40-4 4-fluoroaniline 
• 64-18-6 formic acid 
• 459-59-6 4-fluoro-N-methylaniline 
• 50-00-0 formaldehyd 
• 455-08-3 p-FC₆H₄NMe₃(+)*I(-) 
• 130445-20-4 4-Fluoro-N,N-dimethylaniline N-oxide 
• 124-38-9 carbon dioxide 
• 616-38-6 carbonic acid dimethyl ester 
• 121-69-7 N,N-dimethyl-aniline 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 329-09-9 4-fluoro-tri-N-methyl-anilinium; methyl sulfate 
• 455-08-3 p-FC₆H₄NMe₃(+)*I(-) 
• 50-00-0 formaldehyd 
• 459-59-6 4-fluoro-N-methylaniline 
• 100-23-2 N,N-Dimethyl-4-nitroaniline 
• 130445-20-4 4-Fluoro-N,N-dimethylaniline N-oxide 
• 4316-50-1 N,N-dimethyl-N',N'-diphenyl-1,4-phenylenediamine 
• 121-69-7 N,N-dimethyl-aniline 
• 63029-13-0 4'-(4-aminophenoxy)-N,N-dimethyl benzenamine 
• 1620079-77-7 (E)-methyl 2-benzylidene-4-((4-fluorophenyl)(methyl)amino)-butanoate 
• 1621107-03-6 methyl 2-((4-fluorophenyl)(methyl)amino)benzoate 

Relevant articles and documents

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Mesoionic N-heterocyclic olefin catalysed reductive functionalization of CO2for consecutiveN-methylation of amines

A mesoionic N-heterocyclic olefin (mNHO) was introduced as a metal-free catalyst for the reductive functionalization of CO2leading to consecutive doubleN-methylation of primary amines in the presence of 9-borabicyclo[3.3.1]nonane (9-BBN). A wide range of secondary amines and primary amines were successfully methylated under mild conditions. The catalyst sustained over six successive cycles ofN-methylation of secondary amines without compromising its activity, which encouraged us to check its efficacy towards doubleN-methylation of primary amines. Moreover, this method was utilized for the synthesis of two commercially available drug molecules. A detailed mechanistic cycle was proposed by performing a series of control reactions along with the successful characterisation of active catalytic intermediates either by single-crystal X-ray study or by NMR spectroscopic studies in association with DFT calculations.

Aminomethylation of Aryl Bromides by Nickel-Catalyzed Electrochemical Redox Neutral Cross Coupling

We develop an electrochemical nickel-catalyzed aminomethylation of aryl bromides under mild conditions. The convergent paired electrolysis makes full use of anode and cathode processes, free of a terminal oxidant, a sacrificial anode, a metal reductant, and a prefunctionalized radical precursor. In addition, this method exhibits wide functional group tolerance (63 examples), including some sensitive substituents and aromatic heterocycles. This redox neutral cross coupling provides a more environmentally friendly and synthetic practical protocol for forging C(sp2)–C(sp3) bonds.