4032-52-4

Basic information

• Product Name: Quinoline, 2-(dichloromethyl)-
• CAS NO: 4032-52-4
• Molecular Formula: C10H7Cl2N
• Molecular Weight: 212.078
• Mol File: 4032-52-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Quinoline, 2-(dichloromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 2-(dichloromethyl)-(4032-52-4)
• EPA Substance Registry System: Quinoline, 2-(dichloromethyl)-(4032-52-4)

Safety Data

• Hazardous Substances Data: 4032-52-4(Hazardous Substances Data)

Upstream product

• 91-63-4 2-methylquinoline 
• 87-90-1 trichloroisocyanuric acid 
• 1613-37-2 Quinoline N-oxide 
• 79-36-7 dichloroacethyl chloride 
• 7251-61-8 2-methylquinoxaline 

Relevant articles and documents

Microwave-assisted α-halogenation of 2-methylquinolines with tetrabutylammonium iodide and 1,2-dichloroethane (1,2-dibromoethane)

A simple and efficient methodology permitting the halogenation of 2-methylquinolines into 2-(chloromethyl)quinolines or 2-(bromomethyl)quinolines in the tetrabutylammonium iodide and 1,2-dichloroethane (1,2-dibromoethane) system has been developed for the first time. The halogenation can be rapidly completed with good to excellent yields and high selectivity under microwave irradiation.

Efficient pyridinylmethyl functionalization: Synthesis of 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an acetylcholine release enhancing agent

2-Fluoro-4-methylpyridine (3) is efficiently functionalized by chlorination, hydrolysis and methane-sulfonylation into the novel alkylating agent 7. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare the cognition enhancer drug candidate 1. This process proceeds in up to 37% overall yield and is adaptable for large scale synthesis.

Side Chain Chlorinations of N-Heterocyclic Compounds by Trichloroisocyanuric Acid (TCC)

N-Heterocyclic compounds such as 2-methylpyridines, 2-methylquinoline, and 2-methylquinoxaline react with trichloroisocyanuric acid (TCC) without the addition of an initiator to provide the corresponding chloromethyl derivatives in good yields.