403620-93-9

Basic information

• Product Name: 3-Butyn-1-ol, 4-[9-(1-methylethyl)-6-[(phenylmethyl)thio]-9H-purin-2-yl]-
• CAS NO: 403620-93-9
• Molecular Formula: C19H20N4OS
• Molecular Weight: 352.46
• Mol File: 403620-93-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Butyn-1-ol, 4-[9-(1-methylethyl)-6-[(phenylmethyl)thio]-9H-purin-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butyn-1-ol, 4-[9-(1-methylethyl)-6-[(phenylmethyl)thio]-9H-purin-2-yl]-(403620-93-9)
• EPA Substance Registry System: 3-Butyn-1-ol, 4-[9-(1-methylethyl)-6-[(phenylmethyl)thio]-9H-purin-2-yl]-(403620-93-9)

Safety Data

• Hazardous Substances Data: 403620-93-9(Hazardous Substances Data)

Upstream product

• 403620-90-6 6-benzylsulfanyl-2-iodo-9-(tetrahydropyran-2-yl)-9H-purine 
• 403620-89-3 6-chloro-2-iodo-9-(tetrahydro-2H-pyran-2-yl)-9H-purine 
• 403620-97-3 6-benzylsulfanyl-2-iodopurine 
• 7306-68-5 6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine 
• 87-42-3 6-chloropurine 
• 927-74-2 3-Butyn-1-ol 
• 403620-92-8 6-benzylsulfanyl-2-iodo-9-isopropyl-9H-purine 

Downstream Products

• 403620-94-0 4-(9-isopropyl-6-phenylmethanesulfonyl-9H-purin-2-yl)-but-3-yn-1-ol 

Relevant articles and documents

Cyclin-dependent kinase (CDK) inhibitors: Development of a general strategy for the construction of 2,6,9-trisubstituted purine libraries. Part 1

To validate a proposed solid support synthesis strategy for the construction of 2,6,9-trisubstituted purine based CDK inhibitors, the N-9 THP protected 6-benzylthio-2-iodopurine 11 was reacted with piperidine-2-methanol to give 12. Alternatively, intermediate 11 was converted to the C-2 acetylenyl substituted purine 16 in five steps, involving N-9 alkylation (Mitsunobu reaction), a Pd(0)-CuI-catalyzed acetylene coupling, selective activation of the 6-sulfur substituent and its displacement by ArCH2NH2.