40371-51-5 Usage
Description
(S)-(-)-4-Amino-2-hydroxybutyric acid, also known as (S)-4-AHB, is a chiral amino acid derivative that serves as an important component in various pharmaceutical and chemical applications. It is an analogue of γ-aminobutyric acid (GABA) and exhibits potential inhibitory activity on GABA binding and uptake by the brain. (S)-(-)-4-Amino-2-hydroxybutyric acid is characterized by its white to light yellow crystal powder appearance.
Uses
Used in Pharmaceutical Industry:
(S)-(-)-4-Amino-2-hydroxybutyric acid is used as an active pharmaceutical ingredient for the treatment of certain medical conditions. It is particularly useful in the management of cerebrovascular patients, as it has been shown to increase plasma growth hormone (GH), prolactin, and cortisol levels, which can be beneficial for these patients.
Used in Chemical Synthesis:
(S)-(-)-4-Amino-2-hydroxybutyric acid is used as a key intermediate in the synthesis of various complex organic compounds. One such example is its application in the preparation of 6′-amino-1-N-[(S)-4-amino-2-hydroxybutyryl]-6′-deoxylividomycin A, a compound with potential therapeutic properties.
Used in Antibiotic Production:
(S)-(-)-4-Amino-2-hydroxybutyric acid is an important moiety of butirosin, an aminoglycoside antibiotic. It plays a crucial role in the development and production of this class of antibiotics, which are widely used to treat bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 40371-51-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,3,7 and 1 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 40371-51:
(7*4)+(6*0)+(5*3)+(4*7)+(3*1)+(2*5)+(1*1)=85
85 % 10 = 5
So 40371-51-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H9NO3/c5-2-1-3(6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m1/s1
40371-51-5Relevant articles and documents
α-Hydroxylation of Carboxylic Acids Catalyzed by Taurine Dioxygenase
Wetzl, Dennis,Bolsinger, Jennifer,Nestl, Bettina M.,Hauer, Bernhard
, p. 1361 - 1366 (2016/04/20)
Enzymes still have a limited application scope in synthetic organic chemistry. To expand this, different strategies exist that range from the de novo design of enzymes to the exploitation of the catalytic capabilities of known enzymes by converting different substrates; denoted as substrate promiscuity. We harnessed the synthetic potential offered by the taurine dioxygenase (TauD) from Escherichia coli (E. coli) by studying its promiscuous catalytic properties in the hydroxylation of carboxylic acid substrates. TauD showed high selectivities in the hydroxylation reaction but reduced levels of activity (26 % conversion, >96 % ee). We enhanced the enzyme substrate scope and improved the conversions for the tested substrates by introducing a point mutation at position 206 (F206Y). The conversions of the improved catalyst increased by at least 140 % compared to that of the wild-type enzyme. The number of carboxylic acids that accepted by the enzyme variant doubled from four to eight carboxylic acids.
Hydroxylations microbiologiques de pyrrolidinones-2 (note de laboratoire)
Srairi, Driss,Maurey, Georges
, p. 297 - 301 (2007/10/02)
Microbial hydroxylations of various pyrrolidin-2 ones, especially N-acylated, with Beauveria sulfurescens have been carried out.The regioselectivity depends on the nature of the substituent on the nitrogen atom and the hydroxylation may occur at position 3,4 or 5 of the heterocycle.Hydroxylations at position 3 or 4 occur with low enantioselectivity.
Aminoglycoside antibiotics. II. Configurational and positional isomers of BB-K8
Naito,Nakagawa,Abe,Toda,Fujisawa
, p. 297 - 301 (2007/10/05)
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